Insulin-kamar girma factor: na kullum da kuma sabawa

Insulin-kamar girma factor kira hormone kama a sinadaran tsarin to insulin. Yana shirya cell bambantawa matakai, su ci gaba da kuma ci gaba. Haka kuma an da hannu a glucose metabolism.

Tarihi na samu

Back a cikin marigayi 50s na karni na ashirin, masana kimiyya sun nuna cewa, tsakanin girma hormone (sth), wanda kuma ake kira girma hormone da jiki ta Kwayoyin, akwai wasu tsakiya. Wannan ƙarshe ya taso ne daga gaskiya cewa girma hormone da wani sakamako ne kawai a kan kwayoyin halittar, amma idan aka gudanar a cikin tsoka Kwayoyin, ko da sun kasance a cikin wani gina jiki matsakaici, babu sakamako aka kiyaye.

A cikin 1970s, an gano somatomedins, wanda aka ambata da shiga tsakani da. Suka kira insulin-kamar girma dalilai. Da farko ware uku kungiyoyin na abubuwa: A somatomedin (IGF-3) da kuma B (IGF-2), C (IGF-1). Amma shi aka ƙaddara a 1980s cewa insulin-kamar girma factor-2, kazalika 3 - wannan shi ne kawai wani gwaji da mutum ke sanya, amma a gaskiya shi ba ya wanzu. Kawai ya tabbatar da kasancewar IGF-1.

tsarin

Insulin-kamar girma factor 1 (IGF-1) kunshi 70 amino acid cewa samar intramolecular Hadin da sarkar-gadoji. Yana da wani peptide da ta ɗaure su da jini sunadarai, da ake kira 'yan qasar girma factor. Su ba da damar somatomedins zauna aiki tsawon yawa. Yana daukan sa'o'i da dama, yayin da a free nau'i ce lokaci ba fiye da minti 30.

A hormone ne kama da proinsulin, ga wanda ya samu sunansa. Kuma a cikin kira na somatomedin babbar rawa da insulin kai tsaye. Bayan duk, shi na taimaka wa samun duk ake bukata amino acid da hanta don fara ginshikai na halittar FMI.

kira hormone

Ya ce ci gaban factor dauke endocrine matsakancin samar mataki na ci gaba hormone. An hada da hepatocytes na hanta a mayar da martani ga tsoka mai amsa sigina ruri. A kusan dukkanin tsokoki da mataki na ci gaba hormone da aka bayar da IGF-1. ya samun daga hanta cikin jini, kuma daga can, ta hanyar da shiga tsakani na m sunadarai a kyallen takarda da kuma gabobin. Ya ce hormone stimulates da girma da kasũsuwa, ashe, connective nama da kuma tsokoki. Har ila yau, insulin-kamar girma factor hada da kansa a cikin mutane da yawa kyallen takarda. Idan dole, kowane tantanin halitta zai iya da kansa samar da kansu tare da wannan abu.

Mugunya IGF-1 da hanta ƙaruwa a karkashin mataki na estrogens, androgens, insulin. Amma shi glucocorticoids an rage. An dauke da zama daya daga cikin dalilan da ya sa wadannan abubuwa shafi cikin girma da kuma ci gaba da kwayoyin kuma ta kudi na jima'i maturation.

Properties

IGF a tsoka Kwayoyin exerts girma stimulating aiki da insulin. Yana catalyzes da kira na gina jiki , da kuma slows aiwatar da halaka. Yana kuma canjawa da metabolism, da inganta harkokin kara mai kona.

Insulin-kamar girma factor-1 ake dangantawa da pituitary gland shine yake da hypothalamus. Masa bai iske shi a cikin jini ya dogara da selection na sauran hormones. Alal misali, a wata low taro qara mugunya girma hormone. Kuma qara samar da ci gaban hormone-sakewa hormone. Amma a high matakan da IGF-1 mugunya ce hormone da aka rage.

Tsakanin somatostatin da insulin-kamar girma factor ne dangantaka ta kai tsaye da aka kafa. Tare da karuwa na daya daga cikinsu ƙaruwa da kuma maida hankali na biyu.

Ya kamata mu ma lura cewa amfani da shi a matsayin anabolic 'yan wasa ba shi daraja. An akai-akai da aka buga da sakamakon nazarin wanda koma zuwa korau sakamakon gwajin shan miyagun kwayoyi dake dauke da insulin-kamar girma factor (IGF). Su Hanyar iya haifar da ciwon sukari, na gani hanawa, cuta na zuciya tsoka, neuropathy, hormonal katsalandan. Bugu da kari, wannan abu ne daya daga cikin manyan catalysts girma na cancerous siffofin maruran.

Features IGF

An lura da cewa insulin-kamar girma factor 1 da aka saukar a cikin tsufa da kuma a cikin shimfiɗar jariri, da kuma shi ne mafi girman tsakanin matasa. Amma kamar yadda masu bincike sun gano cewa mazan mutane wanda matakin na wannan hormone ne mafi cancanta ga na sama da iyaka al'ada domin su shekaru kungiyar rayu tsawon. Bugu da kari, sun kasance ƙasa da yiwuwa ga cututtukan zuciya da jini. Dabam, shi ne ya kamata a lura cewa, kara yawan lokacin daukar ciki.

Jini taro a lokacin da rana ne game da wannan. Saboda haka, yana da ake amfani da su tantance da disturbances a ci gaba da girma hormone. Bayan duk, da maida hankali na ci gaba hormone a cikin jini dabam a ko'ina cikin yini, matsakaicin matakin kayyade a cikin dare. Saboda haka, a daidai kafa da adadin ne matsala.

Rage taro na hormone

IGF-1 da aka gano kawai a 1978. Tun daga nan riga mun kashe quite yawa bincike, a sakamakon wanda aka kafa a yawan dokokin. Saboda haka, da kasawa na yara shi ne dalilin da bata lokaci na ci gaba da jiki ci gaba da jariri. Amma kuma m idan insulin-kamar girma factor rage a cikin manya. Bayan duk, shi ne lura da underdevelopment na tsokoki, da rage kashi yawa, canje-canje a cikin tsarin da fats.

Lalacewa ta hanyar rashin IGF iya zama yawan cututtuka. Daga gare su, koda matsaloli, hanta. Sau da yawa cikin hanyar da rage adadin IGF yake akwai wata cuta kamar hypopituitarism. Wannan shi ne yanayin a cikin abin da rami iya dakatar ko markedly rage samar da pituitary ji ba gani. Amma kuma rage samar da somatomedin tare da kasawa da iko, ko, mafi kawai, yunwa.

A karuwa a IGF

Duk da tsanani sakamakon, wanda ya haddasa wani rashin IGF-1, ba lallai ba ne su ɗauka cewa da karuwa a yawan ta ba haka bad.

Saboda haka, idan insulin-kamar girma factor 1 kyautata, shi zai kai ga acromegaly a manya da gigantism a yara. Toddlers cutar aka bayyana kamar haka. Sun fara wani tsanani ci gaban kashi. Wannan shi ne a sakamakon haddasawa ba kawai babban girma, amma kuma ya karu karshen abnormally manyan masu girma dabam.

Acromegaly, wanda ya auku a manya take kaiwa zuwa fadada daga cikin kafar kasũsuwa, ashe, hannuwanku da fuska. Har ila yau, sha da kuma kayan ciki. Wannan na iya kai ga mutuwa saboda cardiomyopathy - wata cuta a cikin abin da ya shafi cardiac tsoka, keta ta aiki.

Mafi sau da yawa dalilin cewa qara insulin-kamar girma factor, a pituitary ƙari. Daga shi za ka iya samun kawar da tare da taimakon magani, jiyyar cutar sankara, da kuma shi za a iya cire surgically. A analysis taimaka sanin yadda nasara far, ko duba ko aiki da aka za'ayi da nagarta sosai. Alal misali, idan ƙari ba gaba daya an cire, da maida hankali IGF aka ƙara.

gudanar da bincike

Don gane asali canje-canje a cikin taro na insulin-kamar girma factor a zamani awon cibiyoyin amfani da IHLA Hanyar. Don haka ya kira immunohemilyuminestsentny analysis. Ya dogara ne a kan rigakafi da martani na antigens. A mataki kadaici bukata abu a haɗe a cikinta tashoshin - phosphors, wanda ke bayyane a karkashin riskar hasken ultraviolet. Matakin luminescence aka auna yin amfani da musamman kayan aiki - a luminometer. A cewar shi, da maida hankali zaba abubuwa a cikin magani.

Survey Shiri

Domin sanin IGF-1, insulin-kamar girma factor, shi ne zama dole su bada gudumawar jini da safe wajabta azumi. Yarda sha kawai a fili ruwa. A tazara tsakanin karshe abinci da shinge na kasa domin gudanar da bincike don zama fiye da awowi takwas. Yana da muhimmanci cewa 30 minutes kafin bayarwa na bincike da haƙuri shi ne a sauran. Domin gudanar da bincike dauki venous jini.

Haka kuma, masana bayar da shawarar ta yi watsi da bincike a lokacin da m na numfashi cututtuka (kwayar ko kwayan asalin) domin ya kawar da ƙarya da sakamakon.

Averages

Lokacin cika siffofin a cikin dakin gwaje-gwaje yana da muhimmanci a saka cikin shekaru. Bayan duk, shi ya dogara da shi sai abin da ya zama wani factor na insulin-kamar girma. A kullum da aka kafa domin kowane category akayi daban-daban. Shi ne kuma dole a mayar da hankali ba a kan Averages amma a kan data daga cikin dakin gwaje-gwaje a cikin abin da kuka dauka gwaje-gwaje. Alal misali, a cikin matasa masu shekaru 14-16 shekaru hormone matakan yana iya zama daga 220 zuwa 996 NG / ml. Kuma a cikin manya, wanda ya kai fiye da shekaru 35, shi ya kamata ba ƙetare darajar 284 NG / ml. Da mazan da haƙuri, da ƙananan matsakaicin matakin na IGF ya kamata. Bayan 66 shekaru, rabon da aka kafa a cikin kewayon 75-212 ng / ml bayan 80 - 66-166 NG / ml.

Yara IGF matakan zai ma ya dogara ne a kan tsufa. A jariri jariran, wanda ba ko da 7 kwanaki, shi ya kamata daga 10 zuwa 26 NG / ml. Amma bayan kwanaki 16 da kuma har zuwa shekara 1, da kudi da aka kafa a 54-327 NG / ml.

ganewar asali da cututtuka

Bayan m da insulin kamar girma factor, yana yiwuwa a gano mai yawan cututtuka. Kara da matakin na shaida ba kawai na gigantism a yara da kuma acromegaly a manya. Wannan zai iya zama wata ãyã daga huhu marurai ciki, na kullum na koda gazawar. Amma ya kamata a lura da cewa, yana yiwuwa ya kara, shan dexamethasone, adrenostimulyatorov alpha, beta-blockers.

Rage IGF matakai a yara iya nuna wada. A manya, da matakin ne sau da yawa a lokacin da rage hypothyroidism, cirrhosis, anorexia nervosa ko kawai azumi. Wani daya daga cikin yiwu Sanadin kullum barci rashi kira da liyafar yawan kwayoyi tare da high allurai estrogens.