Ursodeoxycholic acid: umarnin don amfani, analogs, reviews

Kwanan nan, domin lura da daban-daban hanta raunuka aka ƙara amfani ursodeoxycholic acid. Umarnin don amfani da sinadaran fili nuna ingancinta a da yawa tsanani cututtuka. Menene wannan kaya? Mene ne ursodeoxycholic acid? A abin da kayayyakin shi ne ba?

description

Ursodeoxycholic acid, da yin amfani da abin da aka dogara ne a kan ta asalin da kaddarorin, shi ne wani fari-yellow crystalline foda. Yana yana da wani m iyawa. Wannan abu ne a kullum aiki mutum kwayoyin da aka samar a kananan yawa. Its musamman nauyi ne game da 5% da nauyi na jimlar bile acid. Shi ne hydrophilic kuma yana da wani cytotoxicity. Wannan sunadarai fili ne mai narkewa a cikin barasa da glacial acetic acid, dan kadan mai narkewa a cikin chloroform kuma kusan insoluble a ruwa. Ursodeoxycholic acid da aka ba kunshe a cikin kayayyakin. Yana da aka samu a cikin gall mafitsara da launin ruwan kasa bear.

Ursodeoxycholic acid (UDCA) ne epimer na chenodeoxycholic acid. Da farko an yi amfani da magani daga reflux gastritis da tsagawa gallstones. A tsawon lokaci, shi ya fara da za a yi amfani da, da kuma a wasu cututtuka. UDKH dauke da mafi amintattu na bile acid.

Effect na ursodeoxycholic acid

A ranar, da yin amfani da UDKH ne mai misali far ga daban-daban cholestatic hanta da cutar tare da wani autoimmune bangaren. Ginshikai na mataki na wannan wakili ne don daidaita Kwayoyin na jiki. Its kwayoyin za a iya kafa a cikin membranes na hanta Kwayoyin - hepatocytes. Saboda wannan suna iya sanya su more resistant zuwa lalatattu dalilai. Wannan hepatoprotective wakili na da choleretic sakamako. UDKH rage cholesterol kira a cikin hanta da kuma hana ta sha a cikin hanji. Wannan magani lowers kuma kiwata lithogenicity bile acid abun ciki a cikinta. Yana kara habaka na ayyuka na lipase, pancreatic da kuma na ciki da mugunya. Ursodeoxycholic acid na da hypoglycemic sakamako da kuma stimulates samuwar kuma rabuwa da bile, rage cholesterol.

Wannan magani ni'ima m ko cikakken tsakiyan nonon na cholesterol duwatsu. Wannan shi ne dalilin da ya sa aka yi amfani da mafi sau da yawa. Sadar da cholesterol, shi qara solubility na lu'ulu'u, wanda abubuwa deleteriously a kan gallstones. UDKH yana immunomodulating mataki wanda shi ne ya kara da lymphocyte aiki, rage magana da daban-daban antigens a kan membranes na hepatocytes. Ana rinjayar da yawan T-lymphocytes, rage yawan eosinophils.

UDKH rage taro na cholesterol a cikin bile ta watsawa da kuma miƙa mulki na abu a cikin wani ruwa crystal lokaci. Ana rinjayar da enterohepatic wurare dabam dabam na bile salts. A sakamakon wannan rage reabsorption a cikin Gut na na ciki hydrophobic da mai guba mahadi. Wannan magani yana da wani kai tsaye hepatoprotective da choleretic sakamako. Ursodeoxycholic acid, daga abin da sake bitar na kwararru a hepatology nuna ingancinta, na iya rage hanta fibrosis a cikin m degeneration.

aikace-aikace

Ursodeoxycholic acid, wanda aikace-aikace da aka yi a karkashin kulawa da halartar likita da ake sa a irin wannan pathological yanayi:

• gaban cholesterol duwatsu sarrafa a cikin gallbladder ko na kowa bututu.

• rashin iyawa da su bi endoscopically ko surgically.

• kullum, atypical, kuma m autoimmune hepatitis .

• gaban cholesterol duwatsu bayan inji da extracorporeal lithotripsy.

• mai guba (miyagun ƙwayoyi, barasa), hanta lalacewa.

• sclerosing cholangitis.

• farko biliary cirrhosis, ba tare da wani alamun decompensation.

• atresia, biliary fili.

• cystic fibrosis.

• kullum aiki hepatitis.

• cholestasis a lokacin parenteral abinci mai gina jiki.

• biliary dyskinesia.

• biliary dyspeptic ciwo da biliary dyskinesia da holetsistopatii.

• kullum opistorhoze.

• nakasar biliary atresia.

• biliary reflux esophagitis da reflux gastritis.

Ursodeoxycholic acid (UDKH) amfani da rigakafin hanta lalacewar jawo by gwamnati na cytostatics da hormonal hana. Kuma an wajabta, da sauran cututtuka da lalacewa ta hanyar stagnation na bile. UDKH sanya wa adjuvant far a hanta dasawa ko wasu sashin jiki.

contraindications

Ursodeoxycholic acid, wanda sake bitar mafi part m, yana da tsanani contraindications. Wadannan sun hada da:

• kumburi cututtuka na gall mafitsara, hanjinsu da bile ducts a cikin m lokaci.

• rentgenopolozhitelnye gallstones da high alli abun ciki.

• toshewa na biliary fili.

• hypersensitivity.

• cirrhosis a lokacin decompensation.

• Crohn ta cuta.

• furta tafka magudi a cikin aiki na pancreas, hanta da koda.

gazawar da amfani

Ursodeoxycholic acid, umarnin don amfani da ya nuna a fili babu m gazawa a aikace, ba sanya jariran zuwa shekaru 3 a kwantena form. Ga su yi amfani da zalunta a slurry hada da wannan magani abu. Har yanzu, masana sun ba da aka gudanar dace da karatu da nufin kayyade sakamako na wannan abu cholelitolitic dangane da shekaru na yaro. A daidai wannan lokaci, karatu gudanar a gaban yara da biliary atresia da kuma wasu hanta cututtuka ba nuna takamaiman yara matsaloli.

Shirye-shirye dauke da ursodeoxycholic acid, ba don mata masu juna biyu ne kawai a lokacin da akayi sakamako na far tare da wannan wakili ne mafi girma daga cikin hadarin m ga haifa ba. Kada mu manta cewa da cikakken kimiyya binciken da sinadaran aminci ga wannan category na marasa lafiya ne wanda ya ciyar. Tun da ba a san ko UDKH ratsa cikin ƙirjinka madara, taka tsantsan da ake bukata a cikin saduwa da miyagun ƙwayoyi a reno mata.

illa

Ursodeoxycholic acid, umarnin don amfani wanda ya nuna ba kawai da gazawa a cikin aikace-aikace, amma har zuwa yiwu illa, na iya haifar da pathological mamaki kamar:

• maƙarƙashiya, zawo.

• tashin zuciya.

• ƙãra transaminases.

• zafi a dama babba quadrant da epigastric yankin.

• rashin lafiyan fata halayen (itching, rash).

• calcining duwatsu.

Jiyya na farko biliary cirrhosis wannan shiri wani lokacin sa da cewa haƙuri yana decompensation canji, bace bayan janyewar samun wannan magani.

rigakafi

Don nasarar litholysis cholesterol duwatsu amfani UDKH bukatar la'akari da wadannan yanayi:

• su size ba fiye da 2 cm.

• ba su samar da inuwa a kan radiograph.

• gallbladder aka aiki kullum.

• ducts kula patency.

• kumfa cike da duwatsu kasa da rabi.

• na kowa bile bututu ba ya dauke da duwatsu.

Abin da sauran hani a kan m ne ursodeoxycholic acid? Umarnin ga wannan likita shirye-shirye na nuna cewa cikin dogon lokacin da magani, wanda shi ne fiye da 1 ga watan, dole ne a kai a kai (1 kowane kwana 30) da za su gudanar saka idanu na hanta transaminases, phosphatase, bilirubin, gamma-glutamyl transferase jini. Gudanar da irin wannan ƙididdiga ne da muhimmanci musamman a cikin na farko watanni 3 na far da UDKH. A tasiri na magani aka tabbatar da X-ray kowane watanni shida da kuma duban dan tayi bile. Ga masu rigakafin komawa na seizures ci gaba da cholelithiasis magani da kuma bayan gama rushe duwatsu. Yana iya dauka da yawa watanni.

A lokacin jiyya UDKH mata na haihuwa bada shawarar yin amfani da abin dogara da hanyoyin da kariya da ciki. Yana iya zama wadanda ba hormonal kwayoyi ko hana dauke da adadi kaɗan na estrogen.

Saki tsari da kuma sashi

Ursodeoxycholic acid, da wanda wa'azi manual bada cikakken bayanin ta liyafar circuitry, aka kerarre a wannan sashi siffofin:

• Capsules da Allunan na 150 da kuma 250 MG.

• dakatar yara.

Sashi UDCA tsananin kafa akayi daban-daban. Ya dogara da tsanani daga cikin mutum yanayin da jiki nauyi. A mafi yawan lokuta, an wajabta ta 10-20 MG / kg per day. Wannan kashi da aka dauka a lokaci daya, a cikin maraice. A tsawon lokaci da far ya dogara da shaida. Wannan magani da ake tunawa a cikin kananan hanji, da kuma bayan 3 hours da jini da aka lura ga ta yi cincirindo. Constant liyafar medicaments dauke da ursodeoxycholic acid, ya sa shi cikin primary bile acid a cikin jikin mutum. Wannan abu da aka hõre wani iri-iri-canje da kuma karshe sakamakon yana fitarwa a matsayin metabolites a tumbi da fitsari.

Duration na far ne m da halartar likita. Yana iya zama daban-daban dangane da irin cuta. A wasu tsanani lokuta, da liyafar UDKH kwayoyi yana for shekaru.

Hulda da sauran kwayoyi

A wani hadin gwiwa liyafar da UDKH "Cyclosporine" unpredictable ƙaruwa sha na karshen. A cikin jini da cika fuska qara taro na magani shirye-shirye. A rare lokuta da liyafar UDKH lokaci guda tare da shirye-shiryen "Ciprofloxacin" karshe taro rage-rage.

Ursodeoxycholic acid (analogues)

Ursodeoxycholic acid (capsules, Allunan) kerarre karkashin sunaye daban-daban. Irin wannan jamiái bambanta excipients shiga abun da ke ciki. Saboda haka, kasuwar iya saduwa da wadannan kwayoyi da ursodeoxycholic acid:

• Capsules "Ursosan" wajabta far yaxuwa cutar hanta, cholelithiasis, tare da biliary reflux gastritis da reflux esophagitis, primary cirrhosis, kwayoyi da kuma mai guba hanta lalacewa, cholecystectomy, barasa cuta, sclerosing cholangitis, Biliary atresia, nonalcoholic steatohepatitis. Ursodeoxycholic acid ( "Ursosan") da ake amfani da rigakafin hanta raunuka.

• Allunan "Ukrliv" suka riƙi a hanta hanawa, kullum hepatitis, cholelithiasis.

• Capsules "Ursofalk" zabi ga daban-daban cututtuka na gallbladder da hanta, tare da cholestasis, a rage wasu hanta aiki, dagagge cholesterol matakai. Wadannan sun hada da primary biliary cirrhosis da sclerosing cholangitis, reflux gastritis da reflux esophagitis, hepatitis na daban-daban etiology, cholesterol duwatsu, cystic fibrosis, mahara raunuka na hanta, bile stasis. Wannan shiri da ake amfani da matsayin prophylactic da hanta lahani a lokacin da samun m kwayoyi.

• Allunan "Ursodeks" suka riƙi a biliary cirrhosis ba tare da decompensation cututtuka da kuma reflux gastritis. Suna amfani da soke kananan cholesterol duwatsu a cikin al'ada aiki na gall mafitsara.

• Capsules "Ursodez" amfani da su karya saukar cholesterol duwatsu, da magani daga reflux gastritis, domin symptomatic far ga primary cirrhosis na hanta da babu alamun decompensation.

• Capsules "Ursolizin" zabi ga rushe cholesterol duwatsu, da kuma symptomatic magani daga biliary cirrhosis, gallbladder cholesterosis da reflux gastritis. Da miyagun ƙwayoyi da ake amfani a cikin hadaddun far ga marasa lafiya da kullum hepatitis da cirrhosis.

• Capsules "Choludexan" amfani domin lura da uncomplicated cholelithiasis, na kullum aiki hepatitis, giya da mai guba hanta raunuka, nonalcoholic steatohepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, cystic fibrosis, biliary dyskinesia, reflux gastritis da reflux esophagitis.

• Capsules "Urdoksa" cewa an wajabta, a primary biliary cirrhosis, ba tare da wani alamun decompensation, reflux gastritis. A miyagun ƙwayoyi ya da kyau dissolves da kananan da kuma matsakaici cholesterol duwatsu, yayin da rike al'ada aiki na gall mafitsara.

• Capsules "siginan C", raba aikinsa a uncomplicated cholelithiasis, primary cirrhosis, m da kullum hepatitis, sclerosing cholangitis, atresia intrahepatic fili, reflux gastritis da reflux esophagitis, cholestasis, a lokacin parenteral abinci mai gina jiki, biliary dyskinesia, cutar hanta, da cystic fibrosis, mai gepatoze, dyspeptic syndromes. A shirye-shiryen da ake amfani da rigakafin hanta lalacewa a cikin yin amfani da hormonal hana kuma cytostatics, dutse samuwar a kiba.

Ursodeoxycholic acid, analogs wannan abu da ake dauka kawai wajabta ta likita.