Short peptides da polypeptides matsayin wani ɓangare na wasanni abinci mai gina jiki. Abin da zabi?

Peptides ne mai rare nufin wanda aka yi amfani da tsarin a cikin shirye-shiryen da wasanni abinci mai gina jiki na 'yan wasa a son da masu sana'a wasanni [3]. All peptides - wasanni abinci mai gina jiki da aka gyara - za a iya raba 2 kungiyoyin: short (kananan) peptides da polypeptides ( "babban"). A peptides an hada da sauki gyara - amino acid. Idan wani peptide dauke da karamin yawan amino acid, misali 3 ko 4, - shi ne mai gajeren peptide. Idan peptide ne 20-30 amino acid, kuma mafi - shi ne mai polypeptide. Polypeptides - wannan shi ne kusan guda a matsayin cewa sunadaran - key kwayoyin a jikin mu. Me ya sa yake da muhimmanci rabo a cikin gajeren peptides da polypeptides? Daga cikin tsawon na peptide dogara ga ta aiki, yadda ya dace da kuma kariya a lokacin da amfani a wasanni abinci mai gina jiki.

A halin yanzu rare a matsayin abinci mai gina jiki da wasanni aka gyara su ne polypeptides da inganta mai kona, kara tsoka taro, kara rigakafi, inganta overall kiwon lafiya. Duk da haka, suna da gagarumin drawbacks. Polypeptides, musamman peptide ji ba gani, na iya zama m tare da juna, rushe da na halitta hormones a cikin jiki. Bugu da kari, duk da "babban" peptides ne waje da jiki da kuma zai iya sa rashin lafiyan halayen. High jiki aiki da kullum gwaje-gwaje da dan wasa, sau da yawa taimakawa wajen rage a rigakafi, wanda kara qara gefen rashin lafiyan halayen daga yin amfani da polypeptides. Saboda polypeptides sukan ware daga dabba kwayoyin [2, 3, 9], sa'ba tsaftacewa fasahar in su cutarwa impurities iya zama ba - waje sunadarai, DNA, niƙaƙƙun gaɓãɓuwa, ƙwayoyin cuta, prions, wanda kuma mallaki immunogenicity (ikon sa alerji) kuma zai iya kai ga ci gaban cututtuka.

Shin yana yiwuwa a yi haka, don ci gaba da amfani Properties na bioregulatory polypeptides kuma a lokaci guda cire su shortcomings? Haka ne, yanzu ya zama zai yiwu. A sakamakon shekaru na bincike, an gano cewa, kowane polypeptide ne mai aiki cibiyar - cewa wani karamin bangare na shi, wanda shi ne ke da alhakin aiki da peptide. Bisa bincike na da abun da ke ciki na polypeptides bisa ga wani musamman fasahar Ideal Pharma GmbH short peptides an halitta, kunsha na 2, 3 ko 4 amino acid sharan [5, 6, 7]. Irin wannan short peptides ba dole don ware daga dabbobi tsokoki, da kuma suka za a iya hada chemically. Shi ne mafi aminci saboda roba peptides ba dauke da sinadaran da sa allergies. Kamar wancan IPH short peptides a kan tsarin gaba daya m zuwa na halitta aiki (aikin) polypeptide kwayoyin cibiyoyin da ba su gane ta jiki kamar yadda kasashen waje abubuwa. Yana da muhimmanci a lura da cewa short peptides IPH, kasancewa gaske "aiki" na wani polypeptide kwayoyin amfani a wasanni abinci mai gina jiki a matakan ƙananan fiye da "manyan peptides."

Wani muhimmin amfani na IPH short peptides ne su ikon da aka fi samamme ta jiki idan aka kwatanta da polypeptides. Ta yaya wannan ya faru? Sunadaran da polypeptides shigar da jiki da abinci, shigar da ciki da kuma hanji. Akwai suna tare da taimako na musamman enzymes (peptidases) "yanka" a cikin karami, niƙaƙƙun gaɓãɓuwa - short peptides kunshi 2 ko 3 amino acid sharan. Sa'an nan short peptides shigar da jini da kuma hawa zuwa tsokoki da kuma sauran gabobin da kyallen takarda, wanda da kullum da sakamako. Mafi yawa daga cikin polypeptides, wanda muka sami matsayin wani ɓangare na wasanni abinci mai gina jiki zai zama "yanka" peptidase kuma ba zai yi da ake so sakamako, ko da sakamako zai zama mafi rauni. A cikin wannan gajeren IPH peptides wani bangare ne na wasanni abinci mai gina jiki nan da nan zai daga ciki da kuma hanjinsu shiga cikin jini da kyallen takarda, ba tare da keta. A halin yanzu Ideal Pharma GmbH tsara da kuma hada jerin gajeren peptides, kira IPH, domin Pharmaceutical, abinci, kwaskwarima da kuma wasanni masana'antu, wadda ta da da na rigakafi, juyayi da kuma endocrine tsarin, da antioxidant Properties, kunna metabolism da kuma bauta ga rigakafin ciwon daji da kuma ya karu longevity [5, 6, 7, 8]. Ya kamata a lura cewa polypeptides ba ko da yaushe san ainihin inji na nazarin halittu aiki, alhãli kuwa a gare short peptides IPH Irin wannan nazarin rike da sauƙin kuma za mu iya zuwa genes gano dukan peptide mataki inji [1, 5, 6, 7, 8, 10 ]. Wannan ba ka damar amincewa shirya domin inganci da kuma aminci daga short IPH peptides samar da Ideal Pharma GmbH (Jamus).

Saboda haka, short peptides IPH, da ciwon duk da nazarin halittu da sakamakon polypeptides, mai lafiya, ba-immunogenic, da kimiyya-tushen tsarin ba da aikin da yake mafi kyau bayani matsayin wasanni abinci mai gina jiki aka gyara [4] da vector na ci gaba na zamani da pharmacology da kwayoyin magani.

Sources tabbatar da inganci da kuma aminci daga short peptides

1. Ashapkin VV, Linkov NS, Havinson VH, Vanyushin BF Epigenetic sunadaran peptidergic tsari na gene magana a cikin tsufa adam Kwayoyin // Biochemistry. - 2015. - V. 80, Issue. 3. - P. 374-388.
2. Zilov NE Protein aka gyara a cikin na musamman abinci ga wasan // Gina Jiki. - 2014. - T.83, №53. - C. 133.
3. Mezenova NY, vertuhaya VV, Volkov VV, Baydalinova LS Mezenova OJ Tabbatar da dalilin da fasaha sigogi na powders na aiki peptides daga kifi Sikeli a matsayin wani ɓangare na Bio-samfurin da wasanni abinci // gabatarwar daga cikin jami'o'i. Aiyuka Chemistry da fasahan ilimin halittu. - 2016. - №2 (17). - S. 104-114.
4. Havinson VH, Trofimova SV, Trofimov AV, Kachan EY, Wiener Usmanov IA Terekhina RN, Kryuchek ES, EA Pyrozhkov Hanyar dangane da kara matakin shirye-shiryen babban aji gymnasts amfani da musamman jiki horo da kuma peptide bioregulators. // Jagororin. - St. Petersburg.: St. Petersburg Bio-tsari da kuma Gerontology Cibiyar. - 2013. - 44 p.
5. Khavinson V.Kh., Polyakova VO, Linkova NS, Dudkov AV, Kvetnoy IM peptides tsara Cortical Thymocytes bambantawa, yaduwa, da kuma apoptosis // Journal of amino acid. 2011. ArticleID 517137. P. 1-5.
6. Khavinson V.Kh., Tendler SM, Rfsyanenko NA, Tarnovskaya SI, Linkova NS, Ashapkin VV, Yakutseni PP, Vanyushin BF Tetrapeptide KEDW Interacts tare da DNA da kuma shirya Gene Zancen // American Journal of ilimin halittu da aikin likita Sciences. - 2015. - Vol. 7, N3. - P. 156-169. Khavinson V.Kh., Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkovan.S., Ashapkin VV, Polyakova VO, Basharina VS, Bernaotte A. peptide Regulation na Gene Zancen da kuma Samar Da Sunadarai a Bronchial Epithelium // Huhu. - 2014. - Vol. 192. - P. 781-791.
7. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV The peptide semax rinjayar da magana daga genes alaka da rigakafi da kuma jijiyoyin bugun gini da tsarin a bera kwakwalwa mai da hankali ischemia: genome-fadi transcriptional analysis // BMC Genomics . - 2014. - Vol. 15. - P. 228.
8. Stadnik J., Kęska P. Nama da fermented nama kayayyakin kamar yadda wata majiya na bioactive peptides // ActaSci Pol .Technol. Aliment. - 2015. - Vol. 14, N 3. - P. 181-190.
9. Sweetwyne MT, Pippin JW, Eng DG, Hudkins KL, Chiao YA, Campbell MD, Marcinek DJ, Alpers AZ, Szeto HH, Rabinovitch PS, Shankland SJ The mitochondrial-niyya peptide, SS-31, da inganta glomerular gine a beraye na ci-gaba shekaru // Koda Int. 2017. S0085-2538 (16) 30652-4.