Proton pump inhibitors: injin aiki da aikace-aikace a magani

By proton famfo hanawa ne rukuni na pharmacological jamiái cewa rage kudi na mugunya hydrochloric acid a cikin ciki. Ciwon kai tsaye sakamako a kan secretory canaliculi, su yadda ya kamata kai da ake so warkewa sakamako ulcers, erosive gastritis, Gerd. Abin da ya ƙunshi rukuni ya haɗa da sautin kwayoyi kamar sunadaran sinadaran, amma tare da magungunan pharmacodynamic daban-daban, wato, kwayoyi kusan daidai sun shafi kwayoyin masu asiri, amma sunyi a cikin nau'o'i daban-daban kuma a cikin rates daban-daban.

Proton pump inhibitors: lokacin da kwayoyin effects da kwayoyi

Proton famfo shi ne tsarin gina jiki mai gina jiki wanda ke tsara shigarwa da ions a cikin lumen daga ciki. Ya ƙunshi abubuwa biyu masu kama da juna, wanda ake kira "subunits". Na farko shine furotin na musamman kuma an gina shi da amino acid. A cikin membrane na tantanin halitta, yana nuna hali a hanya ta musamman, ta tsallake shi sau 10, wanda zai haifar da kafawar haruffa 5 na canal secretory. Wucewa ta cikin rami na ions fada a cikin ciki lumen da kuma samar da acidification na matsakaici da kuma fadowa hydrogen index. Bugu da ƙari, yana cikin ɗaya daga cikin madaukai cewa cibiyar mai aiki na gina jiki tana samuwa - jerin jerin amino acid 800 wadanda ke haifar da ƙaddamar da ATP, babban maɓallin makamashi na tantanin halitta.

Sauran subunit wani sunadaran gina jiki, watau, ya ƙunshi jerin polypeptide da aka umarta bisa ga wani tsari da jerin glycoprotein. Sashin ɓangaren kwayoyin yana waje da cytoplasm, kuma ɓangaren glycoprotein wataƙila wata ƙungiya mai karɓa ta karɓin extracytoplasmic dake kama da siginar don kunna H + \ K + -ATPase enzyme. Bugu da ƙari, ɓangaren sunadarai na kwayar ta ƙetare membrane sau ɗaya, wanda ya nuna muhimmancinsa a matsayin haɗin haɗi tsakanin mai karɓar mai karɓa da kuma na farko da ke da alhakin aiwatar da aikin maganin motsa jiki don kira na protons.

Daidai ne, ana iya ƙaddamar da tsarin gyaran furotin na sirri na ɓoyayyen kwayoyin halitta a cikin hanya mai sauƙi don kawar da muguncin H + a cikin ɓangaren kwayar. A mafi wajaba embodiment - shi ne hanawa na enzyme da alhakin kira da cewa yin proton famfo hanawa.

Amfani da masu hanawa a aikin likita

A magani, proton famfo hanawa an yadu amfani, musamman a gastroenterology, wanda shi ne alaka da su ikon rage acidity na ciki mugunya, kuma ta haka ne rage tsanani da tareda žata sakamako a kan ciki bango, wanda yana da muhimmanci musamman idan aka inflamed. A wannan yanayin, sakamako mai illa ba ya dogara ne akan ilimin ilimin ilimin ƙwayar cuta ba, saboda ta hanyarsa an kawar da rinjayar tasirin yanayi a kan amincin jikin. Har ila yau, da bakan pathologies wanda jiyya ga tasiri amfani da proton famfo hanawa da aka fadada da ciki miki da duodenal miki, erosive da kuma wadanda ba erosive Gerd siffofin.

Daga cikin magunguna mafi yawan sun hada da masu safarar famfo na proton tare da sunayen mai suna omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole da sauransu. Daga cikinsu akwai sunayen kasuwanci, alal misali, "Omez". Magunguna suna samuwa a cikin nau'i na capsules. Ana daukar su a ciki cikin sashi wanda likita ya umurta, wanda ya bambanta dangane da irin nau'in pathology. Wannan yana ba da izini ga karɓan karɓa, saboda akwai ƙungiyar marasa lafiya waɗanda suke kokawa game da lokuta masu tsanani na ciwon daji ko duodenal ulcers. A wasu lokuta, an yi ganawa tare da likita a lokacin shigarwa.