"Kardosal": umurci manual, reviews, bayyanai, analogs

"Kardosal" (kasa da kasa sunan - "olmesartan medoxomil") shi ne wani antagonist na angiotensin II tsoka mai amsa sigina (irin AT1) - primary vasoactive hormone RAAS dangane da ci gaban da muhimmanci hauhawar jini.

Form saki da miyagun ƙwayoyi, da aka gyara

A miyagun ƙwayoyi ne samuwa a Allunan cewa an rufe ta daina kai hare hare. Basic abu, wanda a medicament na olmesartan medoxomil amfani a cikin alluna hada daga 10 zuwa 40 MG ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

Bugu da ƙari, da miyagun ƙwayoyi da aka kara magnesium stearate, microcrystalline cellulose, lactose monohydrate. Har ila yau, kamar yadda karin koponentov amfani giproloza da low sauya giproloza. A harsashi da aka halitta daga titanium dioxide da kara talc da hypromellose.

pharmacological effects

An zaci cewa da miyagun ƙwayoyi "Kardosal" mukaddashin a kan kwayoyin, na taimaka wa tarewa da sakamakon angiotensin II, _AT1 tsoka mai amsa sigina sulhu tsakani. A hauhawar jini medicament lowers jijiya matsa lamba, wannan sakamako yana na dogon lokaci. Babu data mai gaskatãwa ga abin da ya faru na hypotension bayan na farko da yin amfani da farko kashi na wani magani da kuma tachycardia saboda dogon lokaci far ( "Kardosal 20", "Kardosal 40"), da bayyanar da janye tare da wani kaifi karuwa a jini.

Da yin amfani da miyagun ƙwayoyi sau daya a rana sakamakon a wani m karu a jini Manuniya. Da ake so sakamako tasowa a kan 24 hours. Yawanci, da hypotensive sakamako aka samu a rana ta sha huɗu na magani, da mafi kyau da sakamakon lura bayan jiyya na game da watanni biyu.

Pharmacokinetics

A sha na da miyagun ƙwayoyi, ta rarraba

Bugu kwamfutar hannu hanzari daukan wani nau'i na pharmacologically aiki metabolite a cikin hanji (saboda da aikin exerted da enzymes) da kuma portal jini (a lokacin sha daga gastrointestinal fili).

A lokacin da warkewa abun da ke ciki na jini jini ba a gano aiki abu canzawa. Average bioavailability ne game da 26%. A kalla matakin da miyagun ƙwayoyi samu a wani talakawan na sa'o'i biyu bayan an soma, tare da kara sashi (guda kashi - 80 MG) na shi qara.

"Kardosal 40", kazalika da kayayyakin da daban-daban sashi na aiki sashi, za a iya dauka ba tare da mayar da hankali a kan ci abinci amfani. Cin kusan babu sakamako a kan bioavailability.

Dangane da jini gina jiki ne kusan cikakken, kuma yayi dace da 99,7%. Duk da haka, lokaci daya amfani "Kardosala" vysokosvyazyvayuschimisya tare da sauran kwayoyi da shi ne ma rage.

Drug metabolism da kuma ta tukar tumbi daga jiki

M miyagun ƙwayoyi samu hanta (60%), da sauran (40%) - kodan. Intrahepatic wurare dabam dabam na aiki abu ne kaɗan. Tun tukar tumbi da aka samar, yafi da hanta, maganin da jamiái "Kardosal da" shi ne haramta idan haƙuri yana biliary fili mai shãmakacẽwa. Bayan maimaita yin amfani da magani partially nuna a kan talakawan for 12 hours. Good sakamako ne lura a kan samun wani sashi daga cikin miyagun ƙwayoyi, wanda yayi dace da dama allurai "Kardosala". A gagarumin sakamako ne yanzu kuma bayan kwana goma sha huɗu na magani, nan jari ba ya faruwa. A wannan adadi, kamar yadda koda yarda ba a shafi daban-daban miyagun ƙwayoyi sashi, shi ne a cikin kewayon daga 0.5 zuwa 0.7 L / h (kamar).

Musamman na asibiti lokuta

Wadanda marasa lafiya da suke da aka samu a take hakkin koda aiki (m, matsakaici, m), AUC karu da 62, 82 da kuma 179%, a lokacin da yanayin ne barga.

Lokacin da hanta matsaloli, dan kadan da kuma moderately bayyana, guda kashi AUC kara wajen taimaka wajen 6 da kuma 65%.

shaidar

Da nada nufin "Kardosal" wa'azi a kan aikace-aikacen sa ganewa na da muhimmanci hauhawar jini.

Bi "Kardosalom" a lokacin daukar ciki ne unacceptable. Idan ciki ne a lura tsari, shi ne zama dole yi na kauda tashe miyagun ƙwayoyi.

Saboda rashin data goyon bayan da aminci da jiyya na nono ciyar a lokacin da magani tsagaita nono.

Don su iya saya "Kardosal" da kuma fara da za a bi da tare da shi, likita dole ne a rubuta takardar sayen magani.

contraindications

Contraindications hada hypersensitivity ga waɗanda abubuwa wanda suke kunshe a cikin halitta, yaro (a karkashin shekaru 18), ciki, nono-ciyar. Bugu da kari, da kwaya ba rubũta a cikin wadannan lokuta:

• toshewa na biliary fili.
• gaban malabsorption ciwo, galactosemia.
• rashin lactase.
• lokaci bayan wani koda dashi.
• koda gazawar a low QC (kasa da 20 ml / min).

"Kardosal" - wani magani da cewa an gudanar da matsananci hankali ga marasa lafiya da yanayi:

• jijiyoyin zuciya jijiya cuta.
• hyperaldosteronism (primary).
• cuta na hanta.
• koda gazawar, a cikin abin da KK ne mafi girma daga 20 ml / min.
• stenosis, rauni tare da mitral ko aortic bawul.
• kullum zuciya maye kwarara;
• cerebrovascular cuta.
• rage cin abinci tare da iyakance sodium ci.
• hyponatremia, hyperkalemia (akwai wani hadarin koda insufficiency, hypotension ko dehydration).
• jihar a lokacin da Bcc rage-rage bayyana amai, zawo.
• stenosis, bugawa wani jijiya kawai koda, dangantakar stenosis, a cikin abin da ya shafa na koda jijiya.
• hypertrophic obstructive cardiomyopathy.
• shekaru fiye da shekaru 65.
• da bukatar diuretics.

Amfani "Kardosala"

"Kardosal" umurci manual bada shawarar yin amfani da 10 MG, wanda yayi dace da farko kashi. Lokacin da kasa daidaita jini kamata a cinyewa a kowace rana zuwa 20 MG na miyagun ƙwayoyi. Rarar kashi na 40 MG miyagun ƙwayoyi da rana ne unacceptable. Daily magani kamata sha daya lokaci, a daya kuma lokaci guda. Ga marasa lafiya da koda matsaloli saukar m zuwa matsakaici mai tsanani, a lokacin da yarda ne a cikin kewayon daga 20 zuwa 60 ml / min, matsakaicin kashi "Kardosala" ba zai iya zama fiye da 20 MG. A lokuta inda akwai bukatar karfafa sakamakon sakamako da aka samar da hadaddun magani (sai dai "Kardosala" tambaya "Hydrochlorothiazide").

illa

A zalunta miyagun ƙwayoyi "Kardosal" umurci manual bada izinin irin illa:

• korau dauki daga numfashi da kuma narkewa kamar tsarin, bayyanar disturbances a cikin musculoskeletal tsarin, urinary fili da kuma kodan, da canza wasu awon sigogi, da ci gaban da wani janar hali cuta (irin illa faruwa sau da yawa).
• ci gaban angina, bayyanar cuta ta shafi juyayi tsarin (wani lokacin bayyana).
• canje-canje a cikin zuciya da jijiyoyin jini tsarin, ci gaban hyperkalemia (wuya gani).

Side effects cewa tashi sosai da wuya bayan samun medicament "Kardosal" umarnin don amfani hada da:

• disturbances a cikin hematopoietic tsarin.
• tari.
• m nau'i na koda gazawar.
• fata matsaloli.
• asthenic ciwo.
• ciwon kai, dizziness bayyanar.
• myalgia.
• convulsive jihar.
• tashin zuciya tare da amai, ciwon mara.
• karuwa da urea, creatinine a cikin jini.
• canje-canje a cikin hanta - karuwa a aiki na da enzymes.

yawan abin sama

Yawan abin sama ne zai yiwu, ta bayyana wata alama akan rage hawan jini Manuniya. A cikin hali na irin wannan a sakamakon magani na bukatar yau da kullum na saka idanu da marasa lafiya. Don kawar da cututtuka cewa raka yawan abin sama nufin "Kardosal", likitoci sun bada shawarar cewa ku yi sake dubawa symptomatic magani da kuma taimaka far wa normalize jini. A hali na yawan abin sama da haƙuri sa a kan mayar kuma ya dauke ya kafafu. Bugu da kari, lokacin amfani da manyan kashi na da miyagun ƙwayoyi ne shawarar yin ciki lavage, ba mutumin da kunna carbon. Akwai bukatar girma sauyawa, kawar da dehydration da kuma maido da ruwa-gishiri balance. Bayani game da yiwuwar tukar tumbi da abubuwa olmesartan medoxomil da dialysis akwai.

tsõratar

A marasa lafiya da suke kafin far maida bi da tare da diuretics da kuma bin wani abinci dake zame amfani da gishiri, na iya haifar da hypotension a sakamakon farko kashi yin amfani da miyagun ƙwayoyi. A wannan sakamakon za a iya lura a marasa lafiya da suke yi ya faru amai ko zawo. Dalilin wannan dauki na jiki - rage Bcc. M taron na wannan yanayi ya kamata a hana. A hadarin da ya faru ya kamata a yi la'akari kafin fara far.

Idan wani mutum ya karya kodan, yana da muhimmanci lokaci zuwa lokaci, duba wadannan Figures sun magani kamar yadda creatinine, potassium. A amfani da ACE hanawa da marasa lafiya da suke yi, an gano cutar ne hyperaldosteronism (primary), ba shi da ma'ana, saboda haka ba su rubũta nufin "Kardosal" (ratings nuna babu mayar da martani ga ACE hanawa).

Ka tuna cewa mai karfi dakushe jini a marasa lafiya tare da atherosclerosis, wanda rinjayar da kwakwalwa tasoshin, ko da jijiyoyin zuciya jijiya cuta zai iya sa da ci gaban m yanayi kamar ischemic bugun jini da kuma tsokar zuciya infarction.

Idan mutum yana yin gyara na zahiri hadaddun kayan ko kuma fitar da wani abin hawa, yana da muhimmanci a san cewa shan "Kardosala" zai iya sa wani tabarbarewar kiwon lafiya (gajiya, wani rauni, dizziness), ko da yake wannan da wuya ya faru.

Saboda da lactose abun ciki a cikin miyagun ƙwayoyi shan shi an hana marasa lafiya da hereditary galactose rashin ha} uri hali. Haka ya shafi marasa lafiya da malabsorption ciwo galactose kuma glucose, lactase karanci a cikin jiki.

Hulda da sauran kwayoyi

A likita dole ne a rubuta takardar sayen magani da kuma gano idan haƙuri aka bi ta wata hanyar su hana maras so halayen. An ba da shawarar yin amfani da biyu "Kardosalom" da kuma wadannan iri kwayoyi:

• yana nufin dauke da potassium.
• gishiri musanya, da suka hada da wadanda na potassium ne ba;
• Potassium-sunã rãyar da diuretics.
• magunguna da shafi potassium matakai a cikin jini magani (kara wannan adadi).

An misali na irin wannan hanyar ne "Heparin". Shi ne iya tasiri cikin abun ciki na potassium a cikin jini. A rashin yiwuwar magani "Kardosal" analogues samar da wata damar yin ta sauyawa.

Tabbatarwa daga cikin antihypertensive sakamako ne kiyaye a lokacin da magani daga sauran antihypertensive kwayoyi da kuma NSAIDs, watau aiwatar da m magani. Far da Hadakar m shafi yin amfani da Cox-2 hanawa, acetylsalicylic acid (kullum kashi - fiye da 3 g). A mataki na angiotensin II tsoka mai amsa sigina antagonists iya zama synergistically influencing da glomerular tacewa da ta raguwa.

Tare da lokaci daya da yin amfani da irin wannan medicaments kamar yadda angiotensin II tsoka mai amsa sigina antagonists, kuma NSAIDs, akwai wani alama na haƙuri da m na koda gazawar siffar. Saboda wannan dalili, monitoring na koda matsayi a farko mataki na magani ya kamata a yi a kai a kai. Irin wannan magani ya kamata shakka sha isasshen ruwaye. Duk da haka, da zai yiwu rage a cikin tsanani daga antihypertensive mataki, inda tabarbarewar an kiyaye akai-akai tasiri na far.

Idan "Kardosal" da aka yi amfani da magani lokaci antacids, wato aluminum hydroxide da magnesium, akwai hadarin rage a cikin bioavailability na aiki abu (matsakaici).

Yana bayar da rahoton reversible ƙaruwa lithium matakai a cikin jini magani da kuma nuna mai guba Properties sakamakon daga sharing da ACE hanawa, angiotensin II tsoka mai amsa sigina antagonists da kwayoyi dauke da lithium. A dangane da wannan hade far saƙon "Kardosalom" da kuma kwayoyi, daya daga wanda aka gyara - lithium, ba da shawarar. Duk da haka, idan irin wannan bukatar ta wanzu, iko da jini ya zama na yau da kullum.

The kudin da kwayoyi, analogs, reviews

Lokacin da assigning "Kardosal" Allunan kamar farashin ba duk da marasa lafiya, don haka suka kasance sha'awar da yiwuwar jiyya ba tare da yin amfani da wasu, mafi tasiri wajen. "Kardosal" tare da abun ciki na 10 MG na aiki sashi za a iya saya don Rub 610, wani magani ga abin da abun da ke ciki na da 20 MG na aiki sashi -. Over 756 goga. "Kardosal", wanda farashin ne game da 860 rubles., Ya ƙunshi 40 MG na babban bangaren.

Kamar yadda wani misalin, lokacin da ka yi zabi wani wajen aiwatar da far, maimakon "Kardosala" ba za ka iya amfani da magani "Olimestra" ko ya zo da wani hade far dogara ne a kan yin amfani da "hydrochlorothiazide", "olmesartan medoxomil". Za ka iya yi amfani da irin wannan takwarorina matsayin "Lozarel 'ko' Cozaar '. Bugu da kari, domin maye dace kwayoyi "Nortivan" "Valsartan Zentiva".

Sane da irin formulations matsayin "Olmesar", "Plaunak". Yawancin lokaci musanya bambanta daga asali kudi, daya daga cikin bambance-bambance ne m farashin da kuma rage bioavailability sigogi, don haka sun kasance ƙasa da tasiri, ko da yake zai iya jimre da aiki.

Analogs suna ko da yaushe amfani karkashin m dubawa na wani gwani, shi wajibi ne don a kai a kai duba jini. Idan kana bukatar ka karba analogue da makaman "Kardosal" fiye da maye gurbin wannan miyagun ƙwayoyi, likita yanke shawarar, shan la'akari da daban-daban lokacin. Bayan ganewa na m events a lokacin jiyya lokacin da analogue ya zama don yin zama dole ayyuka a dace hanya da nufin kawar da nakiyar. A lokacin jiyya da shi wajibi ne don duba sakamako a jiki.

Lokacin da asali ba tare da canza kayan aikin ba zai iya yi, ya kamata ba, baicin kwayoyi kerarre da Turai kamfanonin gwada. A lokacin da shirin ya maye gurbin "Kardosal" Allunan analogues ka kawai da za a zabi mafi ingancin.

Comments barshi cikin likita-haƙuri forums, nuna cewa da miyagun ƙwayoyi "Kardosal" a lokacin jiyya sau da yawa yana sa m halayen, ya fi kowa na da - da ciwon kirji da kuma m gajiya. Amma duk da wadannan m lokacin, da hypotensive sakamako ne ko da yaushe kyau kwarai. Bayyanar illa bukatar game da wani gwani ga shawara, da kuma iya canza magani regimen.

A lura da marasa lafiya da jijiya hauhawar jini da aka saukar, yana da muhimmanci cewa haƙuri ta m iko. Aiwatar da far, haka za su samar da ake so sakamako, kuma bi da jihar na kwayoyin, kuma idan na take hakki - to gyara su a cikin lokaci. Muhimmanci hadedde m, amma miyagun ƙwayoyi jiyya bai isa ba, dole ne mu ma zabi wani ci abinci na musamman. Daga cikin bukata magani yanayi - yarda da m yanayin aiki, yin kawar da miyagun halaye, ta iyakance jiki ayyuka da kuma yarda da sauran majalisarku da abin da aka gabatar don likita da mafi kyau magani sakamakon.