"Clopidogrel": analogues, amfani, manual, farashin

A wasu yanayi, likitoci rubũta magani "Clopidogrel"? Umarnin don amfani, analogs, saki form, abun da ke ciki, illa da kuma alamomi ga yin amfani da wannan magani za a gabatar a daki-daki a cikin wannan labarin. Bugu da kari, za ka koyi tamanin da miyagun ƙwayoyi da kuma marasa lafiya ra'ayi game da shi.

Saki tsari da kuma abun da ke ciki

za ka iya saya da miyagun ƙwayoyi "Clopidogrel" A cikin me form? Guide rahoton cewa da miyagun ƙwayoyi da aka saki a cikin nau'i na alluna, wanda mai rufi da wani fim shafi. A daya bororo ƙunshi 14 guda, a cikin banki - 14 ko 28, a cikin wani kwali cuta - 1 ko 2 faranti da magani. Babban aiki sashi ne clopidogrel a hydrogen sulphate form. A karin aka gyara dauke a cikin miyagun ƙwayoyi halitta sun hada da anhydrous lactose, magnesium stearate, pregelatinized sitaci, hydrogenated Castor man, polyethylene glycol 6000 da kuma microcrystalline cellulose. Film shafi, wanda mai rufi kwamfutar hannu kunshi titanium dioxide, hypromellose, aluminum lacquer (dogara ne a kan fenti Ponceau 4 R), da kuma polyethylene glycol 400 da 6000 aiwatar medicament 'Clopidogrel' (price za a nuna a kasa) via sarkar na drugstores, amma kawai a gaban takardar sayen magani.

pharmacological halaye

A miyagun ƙwayoyi jiyya, rage platelet tari jawo by sauran agonists. Mukaddashin magani "Clopidogrel" (umarnin don amfani, price, reviews, da kuma kuri'a na sauran amfani bayanai suna samuwa a kan da yawa likita yanar da kuma gabatar a cikin wannan takarda) sa'o'i biyu, matsakaicin dace asusun for 4-7 kwanaki a karkashin yanayin m 50-100 MG da rana. Antiplatelet sakamako yana tsakanin 7 zuwa 10 days cikin tsawon lokaci na platelet rayuwa.

Pharmacokinetics

Bayan baka gwamnati da miyagun ƙwayoyi "Clopidogrel" (75 MG - misali kashi) ne hanzari tunawa daga cikin gastrointestinal fili, tare da maida hankali a cikin ruwa rabo daga jini ne ta ƙara dan kadan, amma bayan 2 hours, kuma ya kai ga matakin da za a iya ƙaddara (0.025 g / L).

An baje metabolized da hanta. Manyan metabolite ne m wanda aka samu da wani carboxylic acid (kamar 85% fara abu circulating a cikin jini). A talakawan matsakaicin maida hankali bayan maimaita yin amfani "clopidogrel" ne 3 MG / l, shi za a iya lura da sa'a daya bayan ingestion.

Active abu da kuma metabolite mafita daure su jini sunadaran. Sadarwa da ya rage insatiable.

Bayan baka gwamnati na 14C-suna "clopidogrel" kusan rabin kashi bayyana a urination, game da 46% - da faeces a kan 120 hours. T1 / 2 na babban metabolite - 8 hours.

Jikewa metabolite yawa sau fiye da marasa lafiya bayan kai 75 shekara, wannan ba ya canza platelet tari da kuma zub da jini lokaci.

A jini jini a mai tsanani koda taro na metabolite ne daga 5 zuwa 15 ml / min, alhãli kuwa a lõkacin da talakawan cuta mai tsanani daga gare shi ne 30-60. Duk da cewa da hana ruwa guda sakamako a marasa lafiya tare da adenosine diphosphate - jawo platelet tari aka rage, shi ya karu zub da jini lokaci, kazalika a lafiya masu taimako.

shaidar

Shin kana sane, ga abin da dalilai likita wajabta wani magani ga marasa lafiya a matsayin "Clopidogrel"? Analogs, kuma ya nada wani medicament don rigakafin thrombotic rikitarwa na ischemic bugun jini, tsokar zuciya infarction da kuma na gefe jijiya occlusive cuta. Lokaci daya da magani tare da acetylsalicylic acid da kuma "clopidogrel" kamar yadda aka nuna a rigakafin thrombotic rikitarwa, wanda ya zama wani dalili na m jijiyoyin zuciya ciwo.

contraindications

'Clopidogrel' (price a Pharmacy Moscow yankin ne game da 510 rubles) to tambaya counter tare da:

• hypersensitivity.
• m zub da jini;
• haemorrhagic ciwo .
• mai tsanani hanta hanawa.
• outpouring intracranial Pathology da predisposing ga ci gaban zub da jini (huhu da ƙari, exacerbation na peptic miki, hyperfibrinolysis, da tarin fuka).
• lactose rashi (ga sashi siffofin dauke da madara da sukari), hereditary galactose rashin ha} uri, malabsorption ciwo glucose-galactose.

"Clopidogrel": da amfani da sashi

A Allunan bisa ga umarnin, za a iya dauka ko da kuwa abinci. Ga masu rigakafin thrombotic events in marasa lafiya da ischemic bugun jini ko tsokar zuciya infarction, likitoci rubũta kowace rana "Clopidogrel" 75 MG. A m cuta, wadda ana sa ta ci gaba da mai da hankali ischemic necrosis na zuciya tsoka, magani ya kamata a fara daga farko kwanaki. far da yin amfani da "Clopidogrel" - babu fiye da 35 days. Marasa lafiya da ischemic bugun jini iya daukar wannan magani na tsawon watanni shida. Lokacin da thrombotic rikitarwa tasowa a tsakiyan ACS ba tare da dagawa da ST kashi, magani an qaddamar da karbar yarwa loading kashi (300 MG), da kuma kara ba ya dauki fiye da daya kwamfutar hannu per day. Iyakar yadda ya dace ne ya lura bayan watanni uku. A tsawon lokaci da far da 'Clopidogrel' (analogs da generics gabatar a kasa) kada wuce shekara guda. Kan bango na m jijiyoyin zuciya ciwo tare ST kashi tadawa sau da yawa wajabta 75 MG da miyagun ƙwayoyi a kullum tare da wani na farko daya-lokaci amfani da wani loading sashi a hade tare da thrombolytic jamiái da acetylsalicylic acid. Da zarar bayyanar cututtuka bayyana, kana bukatar ka je hade far. Marasa lafiya a kan 75 years of aka ba da jiyya ba tare da wani loading kashi.

yawan abin sama

A karbar magani a allurai wucewa shawarar, evidenced da karuwa a zub da jini lokaci da kuma m rikitarwa. A irin wannan yanayi, za ka bukatar dace magani. A cikin akwati idan kana bukatar wani mai sauri gyara na shafe tsawon zub da jini lokaci, kana bukatar wani transfussion na TM. Babu wani takamaiman maganin guba.

Hulɗarka tare da sauran kwayoyi

Lokaci daya liyafar na "clopidogrel" tare da warfarin sakamakon a wani karuwa a zub da jini kudi, wanda shi ne dalilin da ya sa wannan hade ne sosai a ke so. Yana qara da dama na zub da jini da kuma a lura da wani magani a hade tare da nonsteroidal anti-mai kumburi da kwayoyi, asfirin, glycoprotein hanawa da kuma heparin.

illa

Jiyya medicament 'Clopidogrel' (mai amfani, da price, da hanyar da gwamnati da kuma sashi ne aka bayyana a cikin daki-daki a cikin wannan abu) zai iya haifar da a ke so sakamakon:

• Jini coagulation tsarin: a lokacin watan farko na far sau da yawa bayyana hemorrhage, hematomas bayyana. a kalla - conjunctive hemorrhage. ya zama ruwan dare lokuta - intracranial zub da jini.
• hematopoietic tsarin: a rare lokuta - thrombotic thrombocytopenic purpura, granulocytopenia, anemia, ciki har da pancytopenia, kuma aplastic anemia.
• Juyayi tsarin: lokaci-lokaci bayyana ciwon kai, paresthesia, juwa ko jiri. rare - vertigo. ya zama ruwan dare lokuta - shafi tunanin mutum da rikice da kuma hallucinations.
• Jini da zuciya, sau da yawa an kafa hematoma. wani lokacin da tsanani hemorrhage, vasculitis, saukar da jini.
• Tsarin Numfashi: epistaxis, bronchospasm, na huhu hemorrhage, interstitial pneumonitis, hemoptysis.
• Narkewa kamar fili: zawo, dyspepsia, ciwon mara, zubar da jini daga narkewa kamar fili, gastritis da kuma na ciki miki, amai, flatulence, tashin zuciya, maƙarƙashiya, retroperitoneal na jini, colitis, pancreatitis, stomatitis, m hanta gazawar, hepatitis, ta ƙara hanta enzymes.
• Musculoskeletal tsarin: arthralgia, myalgia, amosanin gabbai.
• Skin: bullous rashes (Stevens-Johnson ciwo da mai guba epidermal necrolysis, erythema multiforme), eczema, erythematous rash, kuma lichen planus.
• Urinary System: hematuria, hypercreatininemia, glomerulonephritis.
• Rashin lafiyan halayen: angioneurotic edema, magani ciwo, urticaria, pseudoallergy dauki.

Lokacin da far tare da wannan magani da zazzabi yana da wuya a lura, wanda aka ba sani a sakamakon karbar medicament, kuma a matsayin alama da na kowa sanyi.

tsõratar

Medicine "Clopidogrel" tare da matsananci hankali a lokacin da shan high yiwuwa na zub da jini a sakamakon m shisshigi, hemostatic cuta. Idan tiyata ake bukata, da kuma antiplatelet sakamako ne sosai a ke so daga gwamnati da miyagun ƙwayoyi ya kamata a jefar da ga mako kafin nada lokaci na tiyata. Musamman kula magani wajabta tsanani take hakki na hanta aiki, wanda zai iya sa hemorrhagic diathesis. Idan alamun wuce kima zub da jini bukatar nazarin hemostatic tsarin. Bugu da kari, da bukatar kullum saka idanu wasan kwaikwayon na aikin ayyuka na hanta. Tsanaki "Clopidogrel" da aka yi amfani da tare da heparin, NSAIDs, warfarin. Lokacin gudanar da gwaji nazarin samu ba carcinogenic da genotoxic sakamako daga cikin miyagun ƙwayoyi, a Bugu da kari, ba saita tasiri a kan zirga-zirga management iya aiki.

"Clopidogrel": analogs da generics

Kamancin (analogs) kwayoyi - mai magani da ciwon guda mataki ko da ciwon guda abun da ke ciki. Abin da magunguna iya maye gurbin magani "Clopidogrel"? Analogs shiri na aiki abu da wadannan: "Kardutol", "Detromb", "Agregal", "Trombeks", "Klopilet" "Trocken", "Plavix", "Plagril", "Plogrel", "Targetek", "Egitromb" "Clopidogrel Teva,".

Kowane miyagun ƙwayoyi yana da halaye daban-daban, don haka da yin amfani da izini kawai bayan shawara tare da likita.

Ra'ayin game da magani

Abin da mutane suke cewa game da irin wannan shiri a matsayin "Clopidogrel"? Sharhi kan marasa lafiya da suke samu damar canja wurin mai tsanani cututtuka da kuma m shisshigi ne musamman m. Marasa lafiya bayar da rahoton high m mataki na medicament, shi ne duk da haka ba nufi ga liyafar domin kai-magani. Analogues da kwayoyi don taimaka marasa lafiya zabi mafi kyau zaɓi don su a cikin rabo na farashin da ingancin, amma da manufar da tasiri na ikon da ya kamata a danƙa ga wani gogaggen gwani.