Pemphigus vulgaris: haddasawa, cututtuka, magani, magani. autoimmune cututtuka

Ta yaya irin wannan cuta, kamar pemphigus? Magani da kuma bayyanar cututtuka da wannan cuta ana tattauna a kasa. Za ka kuma koyi game da Sanadin wannan cuta tsari da kuma yadda ya ganewar asali.

asali bayanai

Pemphigus, photo wanda aka gabatar a wannan labarin, - wani rukuni na rare amma musamman mai tsanani, debilitating da yiwuwar m vesiculobullous autoimmune cututtuka da shafi fata da kuma mucous membranes.

Masana sun gano wadannan iri da cutar:

• pemphigus vulgaris.
• vegetans form.
• ganye.
• seborrhoeic (iya samun sunaye kamar Shenir-Usher ciwo, ko erythematous).

Janar halaye da cutar

Pemphigus vulgaris wakiltar wani category na cututtuka na fata da kuma subcutaneous nama, wanda gudana a cikin kullum form, tare da m dakwai, komowan cutar.

Wannan cuta ne hormone dogara. An halin m Hakika, kazalika da samuwar intraepidermal blisters.

Mafi sau da yawa, pemphigus vulgaris rinjayar mutane masu shekaru 50 ko fiye da shekaru.

Me ake da wannan cuta ya auku? A dalilai domin ci gaba da wannan cuta, akwai kawai shiriritar.

Pemphigus: mafi m dalilai

Kafin jiyya, da cuta a cikin tambaya da matukar muhimmanci a gano dalilin da ya sa shi ne wani autoimmune cuta tashi daga wani musamman haƙuri. Abin baƙin ciki, gano hanyar pemphigus ne wuya. Masana suna fafitikar da wannan matsala domin da yawa shekarun da suka gabata. A wannan lokaci da suka sa a gaba a cikin jarrabawa:

• Exogenous dalilai, watau shan magunguna, ciki har da penicillin da kuma Kalam, da kuma daban-daban interferons da sauran abubuwa.
• Na ciki dalilai, ciki har da rigakafi da kuma kwayoyin.
• Jiki dalilai (iya rinjayar samu m konewa da kuma radiation).
• Endocrine (msl hormonal gazawar a cikin mutane).
• Ƙwayoyin cuta (Herpesviruses).
• Shan wasu abinci.

Bisa ga wadannan dalilai, bayanin mai yiwuwa abin da ya faru da cutar, mun gama: pemphigus vulgaris iya zama immunological, endocrine, dauke da kwayar cutar, neurogenic, mai guba, da dai sauransu Duk da haka, ya kamata a lura da cewa akwai har yanzu ba a sani ba ko irin canje-canje ne na farko ko suka ci .. secondary yanayi, a mayar da martani ga tushen haddasawa.

Saboda haka, rashin iyawa don gane ainihin dalilin da dauke autoimmune cuta muhimmanci hampers ta dace ganewar asali, don haka mutane da yawa sau da yawa ci gaba da tsanani da rikitarwa.

nucleation inji

Ta yaya ne da ci gaban irin wannan cututtuka, kamar pemphigus? Photo farko na cuta, za ka iya gani a wannan labarin. Masana sun ce cewa dalilin wannan pathologic autoaggressive tsari ne da samuwar antibodies zuwa sunadarai na ga iyali na desmoglein. A karshen wakiltar wani irin "manne" suna shiga m epidermal Kwayoyin via musamman a haɗa abubuwa, wanda ake kira desmosomes.

Da zarar kunna lymphocytes da kuma autoantibodies kai farmaki da desmogleins, epidermal Kwayoyin suna rabu da juna, da kuma epidermis zama porous da kuma "pasted", game da shi, sauƙi peeled kashe da hõre shigar azzakari cikin farji daga daban-daban fungi da kwayoyin cuta. A asibiti yi, wannan sabon abu ne ake kira acantholysis.

A sakamakon na sama aiwatar da mãsu haƙuri yana da blisters a kan fata, kazalika da ta kauri. A lokaci guda suna cike da exudate da kullum fester. A tsawon lokaci, da kumfa peeled kashe daga cikin zanen gado, fallasa da nama da kuma kafa ruɓaɓɓen jini da kuma cutar ulcers. A ci-gaba lokuta, irin wannan samuwar iya rufe ma dukan surface na jiki.

tarihi bayanai

Asali mai dermatological cuta masana ba su sani ba kusan kome ba. Kalmar "pemphigus" ya shafi duk raunuka na mucous da fata, tare acantholysis, samuwar kumfa kuma detachment na zanen gado don ci gaban suppurating miyakunsa. Duk da haka, a shekarar 1964 wata kasida da aka buga a wata mujallar kiwon lafiya, wanda ya canja da fahimtar da likitoci kan cutar a tambaya, kazalika da tsarin kula da bincike da kuma magani. Tun wannan lokacin, gaban antibodies a cikin jini jini da marasa lafiya zuwa desmogleina zama babban rarrabẽwa domin ganewa na pemphigus.

Af, a 1971 ya buga wani labarin a cikin abin da autoimmune yanayi na bincika daki-daki, kuma ginshikai na cin gaban wannan cuta.

Babban bayyanar cututtuka

Blisters a kan fata, sakamakon daga cin gaban maras ɗa'a ko na kowa bladderwort, wakiltar farko alamar rashin lafiya. Ya kamata a lura da cewa irin wannan cuta ya auku mafi sau da yawa. A cewar masana, shi lissafinsu 77% na dukkan gano siffofin pemphigus.

Raunuka a cikin nau'i na kumfa shafi ba kawai fata na haƙuri, amma kuma da mucosa daga cikin bakin da ta makogwaro. Daga baya suka shimfiɗa a kan wani reshe, external al'aurar, fuska da sauransu.

Abin da ya kamata ka sani game da wadannan fata cututtuka? Yawanci, pemphigus tasowa ba zato ba tsammani. Kamar wancan ne a kan lafiya fata zahiri kafa kananan kumfa tashin hankali da cewa da wani appreciable gudun riba flaccid bayyanar. Abin da ke ciki ne m serous ruwa (dan kadan turbid).

Bayan bude papules kafa eroded surface, wanda baya warkar, amma bar burbushi na pigmentation na launin ruwan kasa.

Domin irin wannan autoimmune cuta halin tsanani kullum da kwarara a cikin form. Ya kamata a lura cewa a wasu mutane ba tare da wani magani aka lura maras wata-wata kyautata, wanda aka maye gurbinsu da ƙarin tsanani.

Very sau da yawa tare pemphigus vulgaris sakandare cututtuka (candidiasis).

Saboda da furotin da hasara, ruwaye da kuma dauke da kwayar cutar effects hangen nesa da wannan cuta tare da m siffofin ya fi karfinsu.

Identification cuta

Kamar yadda aka saukar pemphigus vulgaris? Ganewar asali da cutar ne da za'ayi a wani asibiti. A gaban da cutar da aka gano dangane da asibiti cututtuka da kuma sakamakon da ƙididdiga.

Tsohon sun hada da:

• A alama na asbestos-Hansen. Wannan yanayin da aka gano ta latsa yatsa ko a kan wani murfin gilashin (Ina nufin, ba tukuna tsinkãyi) kumfa. Irin wannan hanya facilitates detachment na epidermis a yankin da cewa shi ne m zuwa papules, kazalika da kara da yanki saboda da ruwa matsa lamba a cikin naúra.
• Alama Nikolsky. Wannan yanayin da aka gano a cikin kumfa entrainment guda tare da forceps kuma shafa mai yatsa rabo zahiri m fata a kusa da rauni site. Kamar wancan akwai wani detachment na epidermis.

Ya kamata a lura da cewa maras ɗa'a pemphigus wadannan cututtuka su ne ba musamman, da kuma bincikowa. Ya kamata a tuna cewa wannan manifestations na iya faruwa a sauran cututtuka.

dakin gwaje-gwaje gwaje-gwaje

Yadda ake bincikar lafiya pemphigus vulgaris? Jiyya na autoimmune cuta ya kamata a za'ayi ne kawai bayan da wani likita jarrabawa. Don gane da irin wannan cuta da aka yi amfani da:

• Histological analysis, shafe jarrabawa na smears, ko abin da ake kira yatsa don gane kumfa acantholytic sel (ie, epidermal Kwayoyin cewa sun halartar morphological canje-canje).

Ya kamata a lura cewa a kan tushen da histological bincike na bayanai zuwa kammala da cewa, ci gaban da autoimmune cuta ne ba zai yiwu ba. Wannan shi ne saboda gaskiyar cewa akwai wasu cututtuka da irin wannan hoton.

• Immunofluorescence Hanyar gane kwayuka adibas na immunoglobulin G kuma A, kazalika don gano manyan da qananan antigens - desmoglein 3 da desmoglein-1. Wannan hanya ita ce mafi daidai ganewar asali.

Saboda haka, ganewar asali "maras ɗa'a pemphigus 'an sanya dangane tarawa data na asibiti cututtuka da kuma na asibiti hoto da cutar da kuma sakamakon immunofluorescence dabara da kuma histologic jarrabawa.

magani

A farkon da ci gaban pemphigus vulgaris marasa lafiya wajabta glucocorticoids. Kwayoyi a cikin wannan kungiya samu a tura allurai. A saduwa da miyagun ƙwayoyi a cikin manyan yawa na da muhimmanci shaida. Game da contraindications da sakamako masu illa, su ne na biyu.

Abin da idan cutar a tambaya rubũta glucocorticoids? Shirye-shirye domin lura da maras ɗa'a puzyrchaki iya zama kamar haka: "Prednisolone" "Dexamethasone" da "Triamptsinolon".

Da zarar kyautata na haƙuri, Ina nufin in babu sabon kumfa, kashi na kwayoyi an rage hankali da kuma motsi da goyon bayan domin hana kōmōwa. Irin wannan jiyya na marasa lafiya da dogon isa.

Bayan glucocorticoids, marasa lafiya na iya designate cytotoxic jamiái, immunosuppressants, ciki har da "Methotrexate", "Azathioprine" ko "Prospidin". Su zama dole a cire matsaloli na m halayen bayan ingestion na asali kwayoyi.

Sauran magani hanyoyin

Idan akwai alamomi da cewa a cikin autoimmune cuta marasa lafiya za a iya bi da maganin rigakafi, da kuma kwayoyi cewa goyi bayan zuciya da jijiyoyin jini tsarin gudãnar jini da kuma normalize aiki na hanta da kuma kodan.

Kuma da ake bukata ci na potassium-dauke da jamiái, alli da kuma bitamin. Ga Topical jiyya na pemphigus anti-mai kumburi da kwayoyi, infusions da decoctions na ganye za a iya amfani da su.

Ya kamata kuma a lura da cewa, dangane da yanayin haƙuri shi yiwuwa a sanya irin wannan hanyoyin kamar yadda gemabsorbtsiya, transfussion na jini da kuma plasmapheresis.