Insulin juriya - abin da yake da shi? A rayuwa ciwo ne insulin juriya

Domin mutane daban-daban halin da sãɓãwar launukansa ikon insulin a ta glucose fahimta. Yana da muhimmanci a san cewa mutum zai iya samun wata al'ada ji na ƙwarai to daya ko fiye daga cikin sakamakon daga cikin fili da kuma a lokaci guda - mai cikakkar juriya ga sauran. Next, mun bincika manufar "insulin juriya": abin da shi ne, yadda aka nuna.

Overview

Kafin tafiyad da manufar "insulin juriya", abin da shi ne da kuma abin da ya aikata jingina ta, dole ne a ce wannan cuta ba nadiri. Fiye da 50% na mutanen da tare da hauhawar jini da wahala daga wannan cuta. Mafi sau da yawa, insulin juriya (wanda shi ne, za a bayyana a kasa) da aka samu a cikin tsofaffi. Amma a wasu lokuta shi da aka gano a cikin shimfiɗar jariri. insulin juriya ciwo sau da yawa ba a gano da, ba a fara nuna wani take hakkin tafiyar matakai na rayuwa. Wadanda a hadarin hada da mutane da dyslipidemia ko sosai glucose haƙuri, kiba, hauhawar jini.

insulin juriya

Mene ne wannan? Abin da siffofin ya aikata wannan cin zarafi? Rayuwa ciwo na insulin juriya ne da wani ba daidai ba mayar da martani da kwayoyin zuwa mataki na daya daga cikin mahadi. A ra'ayi ne zartar da daban-daban nazarin halittu effects. Wannan, musamman, da dangantaka da da rinjayar insulin a kan furotin da kuma sia metabolism, gene magana, da jijiyoyin bugun gini endothelial aiki. Illa amsa take kaiwa zuwa wani karuwa a cikin jini taro na fili da ake bukata domin zumunta girma samuwa glucose. insulin juriya ciwo - a hada cuta. Ya unshi wani canji a glucose haƙuri, irin 2 ciwon sukari, dyslipidemia, kiba. "Syndrome X" da kuma ya shafi kãmun juriya na glucose (insulin-dogara).

ci gaban inji

Cikakken bincika ta masana don kwanan wata kasa. Cuta da kai ga ci gaban da insulin juriya na iya faruwa a wadannan matakan:

• Tsoka mai amsa sigina. A wannan yanayin, jihar nuna dangantaka ko karu a yawan rabe.
• A matakin na glucose kai. A wannan yanayin, da gano rage na GLUT4 kwayoyin.
• Pre-receptoral. A wannan yanayin da muke magana game da mahaukaci insulin.
• Postreceptor. A wannan yanayin akwai wani take hakkin phosphorylation da kuma rushewa daga cikin siginar watsa.

Munanan na insulin kwayoyin ne isasshe rare kuma suna da wani asibiti muhimmanci. tsoka mai amsa sigina yawa iya rage a cikin marasa lafiya saboda mummunan feedback. Shi ne saboda hyperinsulinemia. Sau da yawa, marasa lafiya da dakushe tsoka mai amsa sigina lambobin moderately. A wannan yanayin, da feedback matakin ba a dauke a qa'idar da wanda aka ƙaddara abin da mataki na insulin juriya. A Sanadin da cuta an rage da masana zuwa postreceptor keta watsa. By precipitating dalilai, musamman, sun hada da:

• Shan taba.
• Karuwan TNF-alpha abinda ke ciki.
• Rage jiki aiki.
• Kara yawa na wadanda ba esterified m acid.
• Age.

Wadannan su ne main abubuwan da za su iya fararwa insulin juriya akai akai fiye da wasu. Jiyya hada da aikace-aikace:

• Thiazide diuretics kungiyar.
• Beta-adrenergic blockers.
• Nicotinic acid.
• Corticosteroids.

ƙara insulin juriya

Sakamako a kan glucose metabolism auku a adipose nama, tsoka, kuma hanta. Kwarangwal tsokoki metabolizes kamar 80% na fili. Tsokoki a cikin wannan hali abubuwa a matsayin wani muhimmin tushen insulin juriya. Kama daga glucose a cikin Kwayoyin ne da za'ayi ta wajen musamman kai GLUT4 gina jiki. Lokacin da tsoka mai amsa sigina da aka kunna ta insulin jawo jerin phosphorylation halayen. Su ƙarshe haifar a cikin translocation na GLUT4 ga jikin tantanin daga cytosol. Tun glucose ne iya shigar da cell. Insulin juriya (rate za a nuna nan) ne ya sa ta rage a cikin mataki na translocation na GLUT4. An lura karu a yin amfani da glucose fahimta. Tare da wannan, kuma gudanarwa da kama na glucose a gefe kyallen takarda, lokacin da hyperinsulinemia aka mur hanta glucose samar. A irin 2 ciwon sukari shi ne koma.

kiba

An hada da insulin juriya sau da yawa isa. Lokacin wucewa haƙuri nauyi 35-40% ƙwarai saukad da 40%. Located in ciki bango mai nama yana da mafi girma rayuwa aiki fiye da daya wanda aka located a kasa. A lokacin likita lura bayyana cewa karin saki a cikin portal wurare dabam dabam m acid daga ciki zaruruwa tsokani samar da hanta triglycerides.

asibiti ãyõyi

Insulin juriya, wanda bayyanar cututtuka suna hade da rayuwa disturbances iya advantageously za a zarga a cikin marasa lafiya da na ciki da kiba, gestational ciwon sukari, wani iyali tarihi na irin 2 ciwon sukari, dyslipidemia da hauhawar jini. A hadarin da mata tare da polycystic kwai ciwo (PCOS). Saboda gaskiya cewa kiba abubuwa a matsayin alama daga insulin juriya, shi wajibi ne don kimanta da yanayi, a kan abin da akwai rarraba adipose nama. Its wuri za a iya ginekoidnomu - a cikin ƙananan sashi na jiki, ko humanoid irin - a gaban bango na peritoneum. Jari a cikin sama da rabin jiki yana da wani karin muhimmanci ashen da insulin juriya, ƙẽƙasasshen glucose juna da ragowa da ciwon sukari, kiba fiye da ƙananan rabo. Domin gano adadin na ciki mai tsoka iya amfani da wadannan hanya: domin sanin da rabo daga kugu karkara, hip karkara da kuma BMI. A rates na 0.8 ga mata da kuma 0.1 ga mutãne, kuma wata BMI mafi girma daga 27 ana bincikar lafiya tare da ciki kiba da insulin juriya. Alamun cutar bayyana zahiri. A musamman a kan fata alama wrinkled, m hyperpigmented yankunan. Mafi sau da yawa da suka bayyana a cikin armpits, magincirõri, a karkashin ƙirãza. Analysis na insulin juriya ne da wani lissafi dabara. Homa-IR da aka lasafta kamar haka: azumi insulin (HU / L) x azumi glucose (mmol / L). A samu sakamakon da aka raba ta 22.5. Wannan zai yi insulin juriya index. Norma - <2,77. Lokacin da wani karkacewa a cikin shugabanci na kara ji na ƙwarai za a iya bincikar lafiya cuta kyallen takarda.

Cuta da sauran tsarin: atherosclerosis

A yau babu guda bayani ga ginshikai na tasiri insulinorezistenotnosti da shan kashi na zuciya da jijiyoyin jini tsarin. Akwai tsammãninsa ya zama kai tsaye sakamako a kan atherogenesis. Yana ne ya sa ta da ikon na insulin a ta da kira na lipids da aka gyara na yaduwa daga m tsoka a cikin jirgin ruwa bango. Tare da wannan za a iya lalacewa ta hanyar arteriosclerosis hade rayuwa cuta. Alal misali, yana iya zama hauhawar jini, dyslipidemia, canje-canje a glucose haƙuri. A pathogenesis da cuta ne na musamman muhimmancin sosai aiki na jijiyoyin bugun gini endothelium. Its aiki ne don kula da sautin na jini tashoshi ta secreting neurotransmitters vasodilation da vasoconstriction. A jihar dokoki insulin stimulates shakatawa na m tsoka zaruruwa da jirgin ruwa bango ta sakewa nitric oxide (2). Bugu da ƙari, ta ikon inganta endothelium-dogara vasodilation muhimmanci canza a marasa lafiya tare da kiba. Haka ya shafi marasa lafiya da insulin juriya. Tare da ci gaban jijiyoyin zuciya jijiya gazawar amsa ga al'ada samuwar kasashe, da kuma fa] a], za ka iya magana game da mataki na farko microcirculatory cuta - microangiopathy. Wannan pathological yanayin da aka lura a cikin mafi yawan marasa lafiya da ciwon sukari (ciwon sukari mellitus).

Insulin juriya na iya haifar da atherosclerosis da disturbances a kan aiwatar da fibrinolysis. Karja-1 (plasminogen activator hanawa) ne a high yawa a cikin m marasa lafiya da kuma obese nondiabetic. Kira na Karja-1 bijirowa proinsulin da insulin. A matakin na fibrinogen da sauran procoagulant dalilai ma ya karu.

Ƙẽƙasasshen glucose juna da ragowa da irin 2 ciwon sukari

Insulin juriya ne da wani factor kafin asibiti bayyanuwar ciwon sukari. Domin rage taro na glucose hadu da beta Kwayoyin a cikin pancreas. Rage maida hankali ne da za'ayi ta kara samar da insulin, wanda a bi take kaiwa zuwa dangi hyperinsulinemia. Euglycemia za a iya kiyaye a cikin marasa lafiya muddin beta Kwayoyin suna iya kula gwada da high matakan da jini insulin zuwa cin nasara da juriya. Daga qarshe, wannan ikon da aka rasa, da kuma taro na glucose qara muhimmanci. A key factor, wanda shi ne alhakin hyperglycemia a kan komai a ciki a kan wani bango na irin 2 ciwon sukari, insulin juriya ne da hanta. Healthy martani ne don rage glucose samar. Lokacin da insulin juriya, da mayar da martani da aka rasa. A sakamakon haka, ya wuce kima hanta glucose samar ci gaba, sakamakon azumi hyperglycemia. Tare da asarar da ikon da beta Kwayoyin don samar da insulin hypersecretion kiwon miƙa mulki daga insulin juriya tare da hyperinsulinemia zuwa ƙẽƙasasshen glucose haƙuri. Daga bisani, jihar da aka canza kama zuwa wani asibiti da ciwon sukari da kuma hyperglycemia.

hauhawar jini

Akwai da dama sunadaran da kai ga ta ci gaba a kan bango na insulin juriya. Abun Lura nuna cewa weakening na vasodilation da vasoconstriction kunnawa iya taimakawa wajen jijiyoyin bugun gini juriya. Insulin inganta jijiya ruri (m) tsarin. Wannan take kaiwa zuwa wani karuwa a jini norepinephrine taro. A marasa lafiya da insulin juriya ya karu da martani ga angiotensin. Bugu da kari, shirye-shirye za a iya keta vasodilation. A dokoki jihar insulin stimulates shakatawa na jijiyoyin bugun gini tsoka bango. Vasodilatation a wannan harka da aka yi sulhu tsakani da saki / ƙarni na endothelial nitric oxide. A marasa lafiya da insulin juriya, endothelial aiki ne sosai. Wannan rage vasodilation ta 40-50%.

dyslipidemia

Lokacin da insulin juriya lalace al'ada fitarwa danniya m free acid bayan cin abinci daga adipose nama. Karuwan taro samar da wani substrate ga inganta kira na triglycerides. Wannan shi ne wani muhimmin mataki a cikin VLDL samar. Lokacin da hyperinsulinemia rage aiki na wani muhimmin enzyme - lipoprotein lipase. Daga cikin ingantaccen canje-canje a cikin bango bakan LDL irin 2 ciwon sukari da kuma insulin juriya kamata a ambata karin mataki na hadawan abu da iskar shaka na LDL barbashi. More mai saukin kamuwa da wannan tsari suna dauke glycated apolipoproteins.

warkewa matakan

Kara insulin ýan za a iya cimma a hanyoyi da dama. Na musamman muhimmancin ne raguwa a nauyi kuma jiki aiki. Rage cin abinci ne mai muhimmanci ga mutanen da suke kamu da insulin juriya. Rage cin abinci na taimaka wa karfafawa a cikin 'yan kwanaki. Inganta ƙwarai mafi zai inganta nauyi asara. Don mutane da a yi niyya insulin juriya, magani kunshi dama, saukarwa. Karfafawa na abinci da kuma jiki aiki yana dauke su da farko da magani mataki. Ga mutanen da suka gano insulin, rage cin abinci ya zama low-kalori. A matsakaici karu a jiki nauyi (5-10 kilo) sau da yawa taimaka wa inganta iko da glucose matakan. Da adadin kuzari 80-90% ne rarraba tsakanin carbohydrate da kuma kitse, 10-20% daga sunadarai.

magunguna

Na nufin "Metamorfin" tana nufin wani rukuni na magunguna biguanide. Da miyagun ƙwayoyi inganta gefe da kuma hanta insulin ji na ƙwarai. A wannan yanayin yana nufin wani sakamako a kan ta mugunya. A cikin rashi na insulin shiri "Metamorfin" m. Na nufin "Troglitazone" shi ne na farko medicament tiazolidinedionov kungiyar wanda aka yarda a yi amfani da USA. Da miyagun ƙwayoyi qara kai na glucose. Wannan yana yiwuwa ya sa ta kunnawa da PPAR-gamma tsoka mai amsa sigina. Kuma game da shi inganta GLUT4 magana, wanda a bi take kaiwa zuwa wani karuwa a insulin-kara kuzari glucose kama. Ga marasa lafiya da suke da wani insulin juriya, magani za a iya gudanar da a hade. A bisa nufin za a iya amfani da a hade tare da wani sulfonylurea, da kuma wani lokacin tare da juna, don samar da wani synergistic sakamako a kan jini glucose da sauran cuta. Da miyagun ƙwayoyi "Metamorfin" a hade tare da wani sulfonylurea qara mugunya, kuma insulin ji na ƙwarai. A wannan yanayin, glucose matakan rage bayan da abinci da kuma a kan komai a ciki. Marasa lafiya da aka sanya da hade da magani, sun kasance mafi kowa manifestations da qarancin ruwa da.