Fosinopril: umarnin don amfani. "Fosinopril": alamomi ga amfani, sake dubawa, analogues

"Fosinopril" shi ne mai hanawa daga cikin enzyme yana juya angiotensin. Wannan miyagun ƙwayoyi yana da tasiri mai tsanani, wanda ya sa ya yiwu a yi amfani da shi a matsanancin matsin lamba daban-daban kuma a matsayin ɓangare na farfadowa. Bugu da ƙari, medicament exerts natriuretic, vasodilating da cardioprotective mataki, shi ne amfani da a hade tare da wasu kwayoyi a lokacin da magani daga zuciya rashin cin nasara.

Pharmacological Properties na Fosinopril

Magungunan magani "Fosinopril" a cikin jiki yana ɗaukar nau'in mota mai aiki, wanda yana da mummunan sakamako akan angzyensin-musanya enzyme. Magungunan miyagun ƙwayar rage ragowar aikin angiotensin 2, yana daidaita tsarin BP na tsarin, yana da tasirin tasirin tasirin.

Ayyukan enzyme na Angiotensin lokacin amfani da maganin miyagun ƙwayoyi 10, 20 da 40 na da muhimmanci a rage tsawon sa'o'i 7 (ba fiye da sa'o'i 2 ba, amma baya bayan sa'o'i 12 bayan shan magani). Yayin rana, yawanta ya rage ta 7-15%.

"Fosinopril" Allunan damar ware tsokar hypertrophy da dilation na hagu ventricle, a gaban irin wannan yanayi taimakawa wajen kawar da nakiyar. Wannan miyagun ƙwayoyi ya hana jigilar aldosterone, wanda ake aiwatarwa a cikin gland, wanda ya inganta aiki a cikin kallikrein-kinin, ya karfafa sakonni a cikin takarda da jini. Godiya ga farfadowa da aka yi amfani da "Fosinopril", da 'yantar da abubuwa da ke inganta karfin jini na kodan, yana da aikin natiri, aikin gyaran. Magungunan miyagun ƙwayoyi suna taimakawa wajen rage aikin arginine-vasopressin da endothelin-1, wanda aikin shi ne vasoconstrictive.

Tare da rage yawan matsa lamba (diastolic, systolic), babu halayen kothostatic da postural tachycardia ci gaba, BCC ba zai canza ba. Babu canje-canje a cikin aikin reflex na myocardium, jinin jini na jinin jini da jini. Babu wani cin zarafi na samar da jini ga fata, gabobin ciki, ƙwayoyin tsoka ƙwararre.

Kamar yadda umarnin don amfani, "Fosinopril", wanda aka yi amfani da shi a kashi guda, yana da tasirin cutar, wanda ke nuna kansa a hankali bayan kimanin sa'o'i biyar. Ana kiyaye sakamakon don awa 24, wanda ya ba da dama don kula da ƙwayar jini a kowane lokaci. Don nuna iyakar sakamako mai yiwuwa, yana ɗaukar makonni da yawa.

A lokacin jiyya tare da "Fozinopril" a cikin hawan jini, zai yiwu a inganta karfin jiki don rage yawan karfin jini. Tare da farfadowa mai zurfi tare da amfani da thiazide diuretics da kuma magani "Fosinopril" an kara furta sakamako mai tsanani. Idan ya cancanta a soke Fosinopril, ƙwayar karuwar ba ta ci gaba ba, ba a nan ba har ma a yayin da aka soke zubar da ƙaranci. Wannan miyagun ƙwayoyi ya inganta yanayin marasa lafiya idan akwai rashin ciwon zuciya na zuciya mai mahimmanci, kazalika da mayar da martani ga jikin jiki.

Game da bayyanar mummunan kwayoyin halitta da kwayoyin halitta a lokacin magani tare da miyagun ƙwayoyi "Fosinopril", umarnin yana nuna rashi. Duk da haka, yin amfani da maganin cytotoxic zai haifar da wasu cututtuka da suka haɗa da aberrations na chromosomal. Nazarin da aka yi akan ƙuda da berayen sun nuna cewa magani na yau da kullum, ba fiye da 400 MG / kg, ba ya haifar da alamun cututtuka. Saboda yin amfani da ƙwayoyin da suka fi yawa, gombin lipomas sau da yawa ya bayyana a cikin jinsi namiji. Rigar yau da kullum na miyagun ƙwayoyi har zuwa 60 MG / kg a cikin berayen ba ya haifar da cututtuka da ke haɗuwa da ganin aikin aikin haihuwa. Lokacin da aka yi amfani da magani ga ratsi masu ciki (kowace rana zuwa 400 MG / kg kowace rana) da kuma zomaye (kwanakin yau da kullum har zuwa 40 mg / kg), maye gurbi, ƙwayar miyagun ƙwayoyi ya shafi halin ciki.

Rashin yin amfani da maganin "Fosinopril" don amfani yana kwatanta jinkirin, ragewa fiye da cin abinci. Dangane da aiwatar da tsarin metabolism na duniya, basa samuwa ba shi da kyau (36%). "Fosinopril" an rushe shi, wannan tsari yana faruwa a cikin jini, hanta da kuma gastrointestinal tract, sakamakon sakamakonsa, an kafa fosinoprilat, wanda yake aiki ne mai aiki. Matsakaicin matakin magani a cikin jiki ana samuwa a cikin sa'o'i uku bayan aikin. Half-rai yakan faru a cikin sa'o'i 12-15. Hadin da ƙwayar plasma ya kusan cikakke - har zuwa 98%, ƙarar rarraba ta ƙananan.

Kwayar miyagun ƙwayar ba ta keta iyakar iyakoki da ƙwayar cutar kwakwalwa ba, yayin da ake kulawa da shi a cikin abun ciki na madara nono. Tare da cirrhosis (giya, biliary), rashin izini ya rage, hydrolysis ya samu sannu a hankali. Tare da raguwa ta raguwa, akwai rushewa na al'ada na yau da kullum na masu aiki na sinadarai, wadanda miyagun ƙwayoyi zasu iya tarawa cikin jiki. Yin amfani da dialysis don kawar da miyagun ƙwayoyi "Fosinopril" daga jiki nuna wani umurni don amfani azaman aiki wanda baya haifar da sakamakon da ake so.

Indiya ga yin amfani da miyagun ƙwayoyi "Fosinopril"

"Fosinopril" an tsara shi ne don rashin ciwon zuciya da hauhawar jini. A cikin akwati na farko, miyagun ƙwayoyi ne tushen tushen farfadowa, a karo na biyu an yi amfani dashi don farfadowa da ilmantarwa.

Jiyya tare da Fosinopril

Yawancin lokaci, kwayoyi suna sha daya ko sau biyu a rana a lokaci daya. A lura da hauhawar jini, an bada shawarar farko don amfani da 10 mg na miyagun ƙwayoyi, daga baya - 20-40 MG. Lokacin da aka hada magani, idan an yi amfani da diuretic "Fosinopril", kai 10 mg na miyagun ƙwayoyi. A wannan yanayin, ana buƙatar saka idanu na yawan jini, iyakar matsakaicin magani na miyagun ƙwayoyi yana da 80 MG kowace rana. Idan an rasa miyagun ƙwayoyi, kashi na gaba ba'a ninki biyu ba. Ana yin jiyya tare da yin amfani da allurai na magani da likita ya ba da shawara, ba za ka iya daukar ƙwayar ƙwayar miyagun ƙwayar ƙwayar cuta ba kuma ƙara yawan yawan amfani da shi, kuma ba za ka iya soke Fosinopril ba tare da tuntubi likita ba.

Kafin shan magani "Fosinopril", umurni ya bada shawarar duba ƙimar BP. Lokacin da ake yin magani, ana kula da matsaloli daban-daban na likita, likita ya kamata kula da yanayin lafiyar mai kulawa akai-akai.

Don rage girman haɗari na bunkasa hauhawar jini, anyi amfani da ƙananan kwayoyi a gaban lokacin kwanta barci. An soke magungunan antihypertensive kwana bakwai kafin fara farawa tare da Fosinopril. Idan an riga an gudanar da magani na diuretic, sannan don rage haɗari na hypotension symptomatic, daidaita daidaitattun gishiri, kashi na diuretic yana ragewa sosai, a wasu lokuta, an dakatar da miyagun ƙwayoyi (kwanaki 4-7 kafin farkon kashi na "Fosinopril").

Bayan ƙananan haɗari na katako tare da Fozinopril, jagoran littafin ya ba ka damar fara bayan kwana uku. Yayin da ake jiyya, ana buƙatar bincike na BP na yau da kullum da kuma duba yanayin jini na jini (duba kafin farfadowa, dubawa ga watanni 3-6 na farfadowa, sa'an nan kuma duba a kowace shekara, sa ido da yawa zai iya zama dole idan akwai yiwuwar neutropenia). Bugu da ƙari, yana da muhimmanci don sarrafa nauyin jiki, duba kodan da kuma matakin creatinine, potassium a cikin plasma, furotin, matakin nitrogen mai nitrogen. A lokacin farfado, dole ne ku bi abinci.

Magunguna wanda ke dauke da hauhawar jini yana da kyau, yawancin miyagun ƙwayoyi suna karuwa sosai (kowace rana), la'akari da canje-canje a cikin karfin jini, har sai sakamako ya iyakar.

Contraindications don shan magani "Fosinopril"

Lokacin da aka tsara fannonin Fosinopril, ana nuna alamomi ga amfani da lokaci ɗaya tare da contraindications. Ba a yi amfani da miyagun ƙwayoyi ba saboda rashin kulawa da abubuwan da aka gyara da sauran kwayoyi masu kama da juna. Ba a ba magani ga marasa lafiya a karkashin shekara 18 da mata masu juna biyu, mata masu shayarwa. Contraindication ne mai tsanani koda maye. Contraindications hada angioedema (idiopathic, hereditary) a matsayin ba a lokacin da saduwa da miyagun ƙwayoyi, kazalika da waɗanda ke da wata tarihin bayyana hyperkalemia, hypotension.

Hawan ciki

Fassarori "Fosinopril" umarnin don amfani sun hana yin amfani a lokacin ciki, tun da magunguna irin wannan zai iya haifar da ci gaban ci gaba da kuma mutuwar tayi.

Idan ciki ya faru a yayin aiwatar da farfadowa, ana buƙatar karyewa daga miyagun ƙwayoyi. A irin waɗannan lokuta, ana yin duban dan tayi don gano cutar ga tayin.

A cikin jaririn da aka haife shi da Fosinopril a lokacin haihuwa, hyperkalemia, hypotension, oliguria. Idan tarin ya fara, yana da muhimmanci don samar da tallafi ga cin zarafin kodadde da kuma duba yawan jini. Idan akwai cin zarafi da kodan kuma don daidaituwa na karfin jini, zubar jini ko dialysis za a iya yi.

Ƙuntatawa ga yin amfani da miyagun ƙwayoyi "Fosinopril"

Idan akwai cututtukan cututtuka mai mahimmanci, dole ne a la'akari da rabo na amfanin da yiwuwar hadarin yayin jiyya tare da "Fozinopril". Umurnai don amfani, sake dubawa ya nuna bukatar yin kasada da kuma amfani ga lissafi a cikin waɗannan lokuta:

• IHD;
• Mai haƙuri yana da kaya mai sutura;
• Gout;
• Ciwon sukari mellitus;
• Angiodema a tarihi;
• Hanyoyin cutar huhu na nakasa;
• Hyperkalemia a cikin kudi fiye da 5.5 mmol / l;
• Rashin haɓakawa;
• Cirrhosis;
• obstructive canje-canje, tare da mai illa jini outflow daga zuciya (aortic stenosis, mitral).
• Ƙarawar zuciya ta hanya mai tsanani;
• Daidaitawa da abincin da ke samarwa da iyakancewar gishiri ko ƙananan sodium a cikin abincin da ake cinyewa;
• Hyponatremia;
• Leukopenia, thrombocytopenia;
• Wasu hanyoyin (dialysis, anesthesia), tiyata;
• Gudun hankalin atherosclerosis, inda ake rinjaye mafi ƙasƙanci;
• Dehydration;
• Rashin ƙimar halitta na halitta fiye da 300 μmol / l;
• Tsoho;
• Hepatitis;
• Matsaloli tare da gwaninta da kuma jinin jiki;
• Stenosis;
• Jihohin da aka rage bcc.

Sakamakon sakamako daga miyagun ƙwayoyi "Fosinopril"

Maganin "Fosinopril" da aka samo don miyagun ƙwayoyi suna nuna yiwuwar bunkasa wasu sakamako masu illa. Zai yiwu akwai abubuwan haɗari a cikin tsarin hematopoiesis da tsarin jijiyoyin jini. Canje-canjen yiwuwar a cikin aiki na tsarin mai juyayi, narkewa, ci gaba da rikice-rikice a cikin aiki na hankula. Wasu marasa lafiya suna fama da canje-canje a cikin matakan gwaje-gwajen da kuma halayen halayen, wanda bayyanar ta shafi fata, tsarin ƙwayoyin cuta. Akwai matsala masu yawa a cikin tsarin numfashi da kuma urogenital. Daga cikin wasu mummunan halayen jiki - hyperhidrosis, asarar nauyi, sanyi, zazzabi, angioedema, edema a cikin jiki na ƙwayoyin cuta ko ƙwayoyin cuta a cikin kwayoyin lymph, lymphadenopathy, exacerbation na gout. Duk wani matsalolin yayin lokacin jinya ya kamata a ruwaito wa likitan. Babban haɗari na illa mai lalacewa yana haɗi da amfani mara kyau na miyagun ƙwayoyi.

Kwafafin magani na "Fosinopril"

Lokacin da magani tare da miyagun ƙwayoyi "Fosinopril" dubawa ya nuna yiwuwar samun kariya saboda sakamakon yaduwar maganin da aka yi shawarar. Tsarin kangewa yana tare da manyan bayyanai na hypotension, ƙananan gazawar, damuwa, damuwa, bradycardia, cin zarafin ruwa-electrolyte balance.

An yi watsi da gyaran ƙwayoyi ko an cire janyewar miyagun ƙwayoyi, an wanke cikin ciki kuma an ba da sihiri ga mai haƙuri. Wajibi ne mutum ya ɗauki matsayi na kwance, yana da muhimmanci a aiwatar da matakai da nufin inganta BCC. Har ila yau, ana buƙatar farfadowa na gwadawa. Harkokin maganganu a wannan yanayin bai bada sakamako mai so ba.

Maganin miyagun ƙwayoyi na miyagun ƙwayoyi "Fozinopril"

Zai yiwu yiwuwar hyperkalemia ya fi girma a lokacin amfani da kwayoyi da suka ƙunshi potassium, maye gurbin, gishiri, additives da potassium.

Sakamakon maganin miyagun ƙwayoyi ya kara bayyana yayin amfani da wasu magungunan da ke da tasirin cutar, da barasa. Wani sakamako mafi rauni fiye da yadda aka sa ran shi ne saboda amfani da abubuwa da ke kunna tsarin renin-angiotensin-aldosterone, estrogens, NSAIDs da sympathomimetics. A irin waɗannan lokuta, dole ne ka ki karɓar waɗannan kuɗi ko maye gurbin "Fosinopril". Ana kiran likitancin ta likitan likitanci. Za'a iya samun yiwuwar haɗuwa da miyagun ƙwayoyi tare da wasu magunguna daga likita.

Analogs, ma'anar miyagun ƙwayoyi "Fosinopril"

"Fosinopril" yana da alamu da analogues. Sakamakon kalmomi suna "Fozinopril-Teva", "Monopril". Daga shirye-shiryen wannan rukuni an samar da su "Fosinopril-OBL", "Fozikard". Daga kalmomi za ka iya zaɓar "Fozinal", "Fosinotek".

Lokacin amfani da Fosinopril ba ya yarda da umarnin yin amfani da, misalai ko analogues an tsara su ta hanyar likita don farfadowa. Ana kiran su "Berlipril", "Renitek", "Ramipril", "Moyex", "Lizinopril". Ga masu sanannun analogues kuma sun kasance "Pre-Starium", "Kashe" da "Enapril". Daga analogues, Tritace, Akkupro, da Captopril za a iya nada su. Matsalar da za a iya yi tare da yin amfani da "Hartil" ko "Ƙwarewar".

Idan an haramta amfani da miyagun ƙwayoyi Fosinopril, umarnin don amfani, analogues ko kalmomin da aka zaba, kwararren ya yanke shawara.

Bayani game da miyagun ƙwayoyi "Fosinopril"

Yana da muhimmanci a zabi magungunan ƙwayar magungunan ƙwayar cuta don mai haƙuri, la'akari da halaye jikinsa. Idan miyagun ƙwayoyi "Fosinopril" ya dace da mutum, matsa lamba yana ragewa yadda ya kamata da kuma illa mai lalacewa ba zai faru ba. Kamar yadda nazarin ya nuna, akwai karuwar cutar karfin jini, lafiyar lafiyar ta inganta. Idan an lura da halayen mummunan jiki, to, an nuna musu rauni, akasari shine cin zarafin dandano, tides, tari.

Babban hawan zai iya haifar da matsalolin da ke tattare da shan kashi na gabobi masu muhimmanci, don haka kuna buƙatar yin farfadowa a cikin lokaci kuma kuyi nazarin bayanin miyagun ƙwayoyi "Fosinopril", analogues, don fahimtar wasu bayanai masu amfani.