Da miyagun ƙwayoyi "Carboplatin": umarnin don amfani, analogues da sake dubawa

Menene zai iya maye gurbin wannan maganin kamar "Carboplatin"? Za a lissafa analogues na wannan magani a ƙasa. Har ila yau, a cikin kayan wannan labarin za a bayar da bayanai game da yin amfani da ma'anar abin da ake nufi, da alamunta, abubuwan da ke faruwa a ciki da kuma contraindications.

Haɗuwa, bayanin, nau'i na magani

A wace hanya ce mijin "Carboplatin" ya samar? Masu sana'a sun ce ana iya sayan samfurin a matsayin fatar jiki na lyophilized na fata domin shiri na wani bayani mai kwakwalwa. Sakamakon aikinsa shi ne carboplatin, da kuma ƙarin - mannitol.

Gudun allurar "Carboplatin", wanda abin da muka gabatar a sama, ana sayar da shi a cikin jinsunan, wanda aka sanya a cikin kwallun kwali.

Pharmacological Properties

Mene ne miyagun ƙwayoyi "Carboplatin"? Umurnai don amfani, rahotanni na bita cewa wannan wani tsari ne mai mahimmanci na asali, wanda ya ƙunshi nauyin karfe kamar platinum.

Masana sun bayar da shawarar cewa aikin aikin wannan kayan aiki shine saboda ikonsa na ɗaukar DNA. A sakamakon haka, an kafa hanyoyin haɗin giciye na intanet, wanda ya canza tsarin DNA kuma ya rage kira. Ana nuna wannan tasiri ne kawai daga lokaci na sake zagayowar salula. Ya kamata a lura cewa hydration na carboplatin, a lokacin da aka samo nau'in maganin miyagun ƙwayoyi, yana da hankali fiye da tsaftace cisplatin.

Sassan siginar kwayoyi na miyagun ƙwayoyi

Ta yaya rarraba miyagun ƙwayoyi "Carboplatin" ke faruwa a jikin mutum? Umurnin da ake amfani da shi yana nuna cewa bayan daɗaɗɗin wannan wakili a cikin nau'in jigilar (intravenous) tsawon minti 60, maida hankali cikin jini kyauta (watau ultrafiltration) da kuma dukkanin platinum ya rage daidai da samfurin samfurin 2 na pharmacokinetics.

Rayuwar rabin platinum na farko shine kusan sa'o'i 2, kuma m T1 / 2 shine 3-6 hours. Ya kamata a lura cewa domin platinum na musamman, wani rabi na farko mai kama da yake na hali, amma yana da rabin rabi (game da rana).

Tare da ci gaba da kula da wannan miyagun ƙwayoyi na tsawon kwanaki 4, ba a kiyaye jariran platinum cikin jini. Wata rana bayan aikace-aikacen wannan magani, kimanin kashi 85 cikin dari na kayan aiki a cikin plasma yana cikin jihar da ke da alaƙa.

Ta yaya miyagun ƙwayoyi "Carboplatin" tafi? Umurin ya nuna cewa ƙwayar da aka ba da shi yafi kisa ta hanyar kodan (kimanin kashi 30 na nau'in gudanarwa ba canzawa).

A cikin mutanen da ke da SC, 60 ml / min kuma fiye da 65% da 70% na asalin da ake amfani da su an cire su don 11 da 23 hours, bi da bi.

Dangane da gaskiyar cewa "Carboplatin" ya kasance kusan gaba ɗaya ta hanyar zane-zane na duniya, kawai ƙananan taro ne aka lura a cikin ƙananan gogewa, wanda ya bayyana ƙananan ƙwayar magungunan ƙwayoyi idan aka kwatanta da cisplatin.

Antitumor magani "Carboplatin": alamomi

A waɗanne hanyoyi ne ake amfani da miyagun ƙwayoyi a tambaya? Bisa ga umarnin, wannan shirin yana nufin don maganin ciwon sukari masu zuwa:

• Oganian ciwon daji;
• Ciwon jiji;
• Magunguna masu ciwon jini a cikin maza da mata;
• Sarcoma osteogenic;
• Ciwon daji na huhu;
• Madulloblastoma;
• Tumors na wuyansa da kai.

Haramta don yin amfani da bayani na jiko

Mene ne contraindications ga miyagun ƙwayoyi "Carboplatin"? An haramta yin amfani da wannan magani idan:

• Abincin nono;
• Magungunan ƙwayoyi na kodan (alal misali, tare da QC ƙasa da 15 ml / min);
• Hanyar ciki;
• Hypersensitivity zuwa carboplatin da wasu kwayoyi, ciki har da platinum;
• Myelosuppression mai tsanani;
• Babban hadarin jini, ciki har da wadanda aka lura a cikin 'yan kwanan baya;
• A cikin yara.

Har ila yau tare da taka tsantsan wannan magani yana wajabta ga:

• Alurar riga kafi;
• Raunin ji;
• Rarraba cikin aikin koda;
• Rage ciwon hakar mai hematopoiesis, ciki har da yanayin bayan radiotherapy da chemotherapy;
• Amfani daidai da kwayoyi nephrotoxic (misali, "Cisplatinum");
• Magungunan cututtuka na maganin cututtuka, fungal da asalin sinadaran.

Magani "Carboplatin": umarnin don amfani

Yaya zan yi amfani da wannan magungunan antitumor? A cewar masana, wannan magani za a iya amfani dasu a monotherapy kuma a hade tare da sauran jami'ai na irin wannan sakamako (alal misali, a hade tare da miyagun ƙwayoyi "Paclitaxel").

Dangane da girman da kuma inda masu haƙuri ke da ƙwayar tumɓir, likitoci sunyi amfani da kwayoyin "Carboplatin". Ya kamata a gudanar da shi cikin hanzari a cikin hanyar jiko don minti 17-55.

Yaya zan yi amfani da miyagun ƙwayoyi "Carboplatin"? Umarnin yana nuna irin wadannan maganganun wannan maganin:

• 100 MG / m 2 na jiki na jiki, kowace rana don kwanaki 5;
• 300-400 MG / m 2 na jiki na jiki, sau ɗaya kowace mako 4.

Ya kamata a lura da hankali cewa tsaka tsakanin gwamnati da wannan magani, tare da nau'in platelet na 100,000 / mm2 da neutrophils daga 1,500 / mm2, ya zama akalla makonni 4.

Bayan kuma kafin aikace-aikace na "Carboplatin" ƙarin haɓakar ruwa, da kuma yin tafiyar diyya mai karfi ba'a buƙata.

Idan mai halayen yana da mummunan ciwo mai tsanani ko matsayi mai tsanani, zai zama dole don rage sashi na miyagun ƙwayoyi ta kashi 26%.

Tare da koda pathologies, haɗarin tasowa masu guba na miyagun ƙwayoyi ya karu sosai, sabili da haka ne aka rage girmansa bisa matakin QC.

A cikin tsofaffi, da kuma tare da ci gaba da maganin myelosuppressive, ya zama dole don rage sashi ta 22-25%.

Kafin amfani da bayani mai jiko, ya kamata a kula da ido don sanin ko akwai wasu abubuwan da ke cikin launi ko ƙetare waje.

Menene za'a iya hade da magani foda "Carboplatin"? Umurni don amfani suna nuna cewa ana amfani da wannan magani a mafita na 5% glucose ko 9% sodium chloride. A kiyaye taro ya kamata 0.5-1 MG / ml.

Dole ne a shirya maganin miyagun ƙwayoyi da kyau kafin amfani, tun da yawancin kwanciyar rai na shirye-shiryen gauraye shi ne rana ɗaya.

Sakamako na gefen

Mene ne mummunan halayen da miyagun ƙwayoyi suka yi "Carboplatin"? Bayani game da wannan kayan aiki yana da'awar cewa zai iya haifar da cigaban waɗannan abubuwa masu ban sha'awa:

• Tsarin gastrointestinal: cikin sa'o'i 11-12 bayan yin amfani da miyagun ƙwayoyi, mai haƙuri zai iya jin nauyin motsa jiki, da zubar da ciki. Rage hašarin emetic halayen amfani da baya liyafar antiemetics, kazalika da intermittent gwamnati na wani medicament kwanaki 5, ko wani ci gaba da igiyar jini jiko na kwanaki. Har ila yau, a wasu marasa lafiya, an lura da halayen halayen, irin su zawo, ciwo na ciki, ƙonewar mucosa na baki da kuma maƙarƙashiya.
• Hanyoyin hematopoiesis: yin amfani da asalin "carboplatinum" zai iya kawar da aikin hawan jini na hematopoiesis. Har ila yau, yawancin marasa lafiya sun bayyana bayyanar cututtuka na anemia, ƙarfin abin ya dogara da sashi na miyagun ƙwayoyi. Sau da yawa ci karo da na asibiti da rikitarwa kamar cutar, zazzabi, zub da jini da kuma buga kwamin na tara.
• Harkokin HC da CNS: akwai yiwuwar samun ci gaba na neuropathy, da kuma karuwar raƙuman hanji mai zurfi, musamman a cikin mutane fiye da shekaru 65. Bugu da kari, akwai alamu na rushewa na CNS. Kulawa na tsawon lokaci tare da magani zai iya haifar da ƙari neurotoxicity.
• Kayayyakin gani: a cikin aiwatar da amfani da hanyoyi da aka yi la'akari da su, akwai yiwuwar matsala ta wucin gadi ko rashin asarar hangen nesa, da hasara na iya ganin haske da rarrabe launuka. Sauyewar hangen nesa da kyautatawa yana faruwa a cikin 'yan makonni bayan an janye miyagun ƙwayoyi. Mutanen da ke fama da nakasar gwargwadon ƙwayar da aka bi da su tare da manyan maganin miyagun ƙwayoyi sun sami makanta.
• Jiran jiji: tare da gabatarwar "Carboplatinum", wasu marasa lafiya sun sha kwarewa, wanda ke nuna kanta a matsayin ɓarna na ji da motsa a kunnuwa.
• Allergies: zazzabi, rash erythematous, pruritus, anaphylactic dauki, urticaria, hypotension da bronchospasm. Abubuwan da aka lissafa za su iya bayyana minti kaɗan bayan kula da miyagun ƙwayoyi. Har ila yau, a rare lokuta, marasa lafiya na iya fuskanci exfoliative dermatitis.
• Kwayar Renal: tare da gabatarwar "Carboplatinum" a wasu marasa lafiya, an yi amfani da ƙananan lokaci da sauƙi a cikin ƙwayoyin miyagun ƙwayoyi da urea a jini. A cikin wannan kullun da kodan ke da wuya sosai. Rashin ƙaddamar da ƙananan ƙwayoyin cuta a kan bayanan amfani da wannan ƙwayar cuta yana ƙaruwa tare da karuwa a cikin kashi, kuma a cikin mutanen da suka biyo baya tare da cisplatin.
• Ƙididdigar zaɓen lantarki: hypocalcemia, hypokalemia, hypomagnesemia da hyponatremia.
• Hanyo: Akwai yiwuwar ƙarar lokaci a cikin yawan bilirubin, ACT da alkaline phosphatase cikin jini. A cikin mutanen da aka magance su tare da manyan maganin miyagun ƙwayoyi tare da ƙwayar launuka mai tsinkayuwa masu launin fata, akwai abubuwan haɗari a cikin aikin hanta.
• Sauran halayen: cututtuka masu ciwo da cututtuka, asthenia, alopecia, rashin tausayi na zuciya, annoba-kamar bayyanar cututtuka, myalgia / arthralgia, rashin lafiyar halayen, cuta na cerebrovascular.

Bayani na Musamman

Mene ne ya kamata marasa lafiya su san kafin amfani da miyagun ƙwayoyi "Carboplatin"? Umurnai, sake dubawa suna jaddada cewa jigilar wannan magani za a iya aiwatar da shi kawai a ƙarƙashin kulawar ma'aikatan lafiyar da ke kwarewa a jiyya. Wajibi ne don saka idanu yiwuwar cututtuka, musamman ma lokacin amfani da allurai na miyagun ƙwayoyi.

A hanyar maganin wannan magani da kuma na watanni uku masu zuwa, marasa lafiya suna buƙatar amfani da ƙwayar ƙwayoyi.

Don shiri, kazalika da aiwatarwar maganin maganin miyagun ƙwayoyi, dole ne a yi amfani da kayan aikin likita wanda basu dauke da aluminum. Wannan shi ne saboda gaskiyar cewa lokacin da yake hulɗar da miyagun ƙwayoyi, ana lura da siffofi da kuma ragewa a tasiri na miyagun ƙwayoyi.

A lokacin kula da "Carboplatinum" ana buƙatar nazarin neurological lokaci, ciki har da tsofaffi da mutanen da suka karbi cisplatin a baya.

Yin amfani da wannan miyagun ƙwayoyi zai iya haifar da ci gaba da illa mai lalacewa, sabili da haka, kafin farkon farawa ya kamata ya zama gwaje-gwaje na jijiyoyin.

Yayin da yake lura da cututtuka na asibiti a jikin ɓangaren jihohi, yana iya zama dole a daidaita ƙwayar "Carboplatin" ko don share shi gaba daya.

Idan samfurin yana samun fata ko idanu, nan da nan zubar da ruwa mai girma. Idan an haɗiye, nemi taimakon likita.

Magunguna kamar wannan

Menene analogs zasu iya maye gurbin maganin "Carboplatin"? Umurni don amfani ba su ƙunshi duk wani bayani game da wannan batu ba. Bayan haka dole ka juya zuwa likita. A matsayinka na doka, masana sun bada shawarar yin amfani da analogs na "Carboplatin": "Cytoplatin", "Texalkus", "Nuni", "Oxiplate", "Oxaliplatin", "Platinol", "Cisplatinum", "Eloxatin", "Platikad", "Plaksat "," Oxitane "," Oxtera "," Exorum ".

Bayani game da maganin antitumor

Yanzu ku san dalilin da ya sa ake amfani da miyagun ƙwayoyi irin su Carboplatin (Carboplatin Teva). An bayyana umarnin don amfani da wannan magani a sama.

Binciken mai haƙuri game da guba da ingancin miyagun ƙwayoyi "Carboplatin" ya saba sabawa. Wasu marasa lafiya sunyi magana game da kyakkyawan sakamako na farfado da cututtukan cututtuka, yayin da wasu sunyi la'akari sosai da mummunar maganin miyagun kwayoyi a jikin kwayoyin halitta da kuma tsarin mutum, da kuma wasu abubuwan ban sha'awa. Masana sunyi jayayya cewa wannan shi ne saboda haƙurin mutum na haƙuri game da kayan aiki na miyagun ƙwayoyi da kuma yanayin da ya dace. A kowane hali, ciwon daji yana bukatar m chemotherapy. Idan magani "Carboplatin" bai dace da mai haƙuri ba saboda dalili daya ko wani, to an maye gurbin shi ta analogues. Wannan maye gurbin maganin antitumor ya taimaka wajen kashi 90 cikin dari.