Antiplatelet jamiái: jerin kwayoyi. Anticoagulants da antiplatelet jamiái, su halaye

Karuwa zub da jini sau da yawa yana sa thrombosis, wadda take kaiwa zuwa tsanani sakamakon, ciki har da mutuwa. Pharmacology ci gaba da damar ceton rayuka da marasa lafiya da irin wannan cuta saboda goyon baya far as samun antiplatelet kwayoyi.

Menene anticoagulants?

Rheological Properties na jini ya buge wani daidaituwa tsakanin coagulation da anticoagulation tsarin. A rike wannan ma'auni a matsayin halitta anticoagulant shiga antithrombin III da heparin, wanda aiki kai tsaye antithrombotic aiki, wato, hana samuwar wani jini gudan jini. Ginshikai na mataki na karshen ake dangantawa samar da wata hadaddun da antithrombin III, sakamakon da samuwar wani aiki antithrombin. Ya, bi da bi, shi ne alhakin dauri ga thrombin, sa shi m - shi na taimaka wa hanawa na thrombus samuwar. Antithrombin III da kanta ma yana anticoagulant kaddarorin da inactivating thrombin, duk da haka, da dauki fitowa sosai a hankali.

Da ikon na heparin tabbatar inactivation na thrombin dogara a kan adadin antithrombin III a cikin jini. Ake bukata kashi gyara ake bukata dangane da bincike. Sau da yawa bukatar nada biyu kwayoyi a lokaci daya - heparin da antithrombin III, a wannan sashi ake zaba akayi daban-daban domin kowane mutum.

Dauri ga antithrombin - ba kawai aiki na heparin. Bugu da kari, yana da ikon rushe fibrin ba tare da sa hannu na plasmin, aka kira ba enzymatic lysis. Wannan dauki samuwar mahadi da dama ilimin aiki abubuwa, ciki har da peptides kuma ji ba gani. Daga cikin sauran siffofin rarrabe danniya da dama enzymes da hannu a cikin kumburi tsari (na rage tsanani), kazalika da kunnawa da lipoprotein lipase da kuma inganta jini ya kwarara a cikin zuciya tasoshin.

Mene ne antiplatelet jamiái?

Shirye-shirye anticoagulants da antiplatelet jamiái suna yadda ya kamata a yi amfani da magani. Wannan sunan samu kudi, wanda hana bonding (tari) na jini Kwayoyin - ja jini Kwayoyin da platelets. Ginshikai na mataki daga cikin wadannan abubuwa ne daban-daban, wanda a yarda da dama kungiyoyin. Antiplatelet jamiái, m jerin kwayoyi da aka kebance su kamar haka.

1. Alli antagonists ( "Verapamil").
2. Enzyme hanawa, wanda sun hada da abubuwa da kashe cyclooxygenase (acetylsalicylic acid, "naproxen", "Indomethacin") da kuma adenylate cyclase da phosphodiesterase ( "Ticlopidine", "Pentoxifylline").
3. Kwayoyi da ta da da samuwar prostacyclin ( "pirazolinov").
4. Prostanoids ( "Prostacyclin" da kuma ta analogues na roba asalin).
5. Kwayoyi da kashe sallama na abubuwa kunshe a platelets ( "Pyracetam").

shaidar

Antiplatelet kwayoyi - kwayoyi wanda sunayen da aka sani zuwa ga mutane da yawa saboda da fadi da aikace-aikace. Babban aikin wannan kungiyar - na thrombosis prophylaxis. Antiplatelet kwayoyi - kwayoyi da yadda ya kamata tambaya a da dama zuciya da jijiyoyin jini pathologies, kazalika da bayan tiyata (afar roba zuciya bawuloli).

Antiplatelet jamiái: jerin kwayoyi da cewa ana amfani da likita yi

Kwayoyi cewa suna cikin wannan rukuni, sallama mai yawa, kuma suka duk suna da nasu peculiarities. Selection na mai magani ya dogara da na asibiti hali. Kuma, ba shakka, kai-magani a cikin wannan halin da ake ciki shi ne bai dace ba.

"Asfirin"

A tsari na hemostasis eicosanoids ne da hannu waxanda suke da samfurin na hadawan abu da iskar shaka na arachidonic acid. Daga cikin mafiya muhimmanci na thromboxane A2, kuma ta babban aiki - tabbatar platelet tari. A mataki na asfirin ne zuwa ga hanawa daga wani enzyme, kira cyclooxygenase. A sakamakon wannan kira ne suppressed tomboksana A2, saboda haka hana thrombus samuwar tafiyar matakai. A sakamako qara lokacin da sake shan miyagun ƙwayoyi saboda jari. Ga cikakken hanawa na cyclooxygenase ake bukata kullum ci. A ganiya sashi rage alama na gefen effects, "asfirin" ko da tare da m amfani. Kashi Ɗaukaka ne unacceptable, tun akwai hadarin zub da jini da rikitarwa.

"Ticlopidine"

A kwayoyi su ne bisa tarewa wasu rabe da suke da alhakin jini clots. Yadda aka saba, a lokacin da ka danganta ga su akwai wani canji na ADP platelet tari kara kuzari da kuma siffa, da kuma "Ticlopidine" damuarn wannan tsari. A siffa daga cikin antiplatelet wakili ne a high bioavailability, wanda aka samu da babban gudun tsotsa. Bayan warware sakamako ne lura ko da ga 3-5 days. A drawback ne manyan yawan illa, ciki har da na kowa tashin zuciya, zawo, anemia da kuma agranulocytosis.

"Clopidogrel"

Antiplatelet jamiái bisa ga irin mataki ne kama da "ticlopidine", amma ta amfani ne in mun gwada low yawan guba. Bugu da kari, hadarin illa a lokacin da shan wannan magani ne da yawa m. A halin yanzu da kwararru ba, baicin "clopidogrel" saboda babu rikitarwa, kamar agranulocytosis da thrombocytopenia.

"Eptifibatide"

Da miyagun ƙwayoyi ba tari da tarewa da glycoprotein, wanda aka located a cikin platelet membrane. Sanya ga igiyar jini bolus, yawanci a angina kuma angioplasty don rage alama na tsokar zuciya infarction.

"Dipyridamole"

Babban sakamako daga cikin miyagun ƙwayoyi - dogara vasodilatation, watau fadada daga jini ba, amma ya bayyana antiplatelet sakamako ne lura da lokacin da a hade tare da sauran kwayoyi. "Dipyridamole" nada tare da "asfirin", idan akwai wani babban hadarin da jini clots. Shi ne kuma zai yiwu a hada da "warfarin", da aka yadda ya kamata amfani bayan da} afar roba zuciya bawul don rage alama na embolisms. A monotherapy sakamako ne kasa pronounced.

Antiplatelet kwayoyi - kwayoyi (jerin: "Elikvis", "clopidogrel" da sauransu), an yi amfani da ko'ina a yi.

contraindications

Nada antiplatelet far bukatar m tarihi, wanda ya hada da bayani a kan comorbidity. A gaban wata cuta da cewa shi ne mai contraindication ga samun magungunan a cikin wannan kungiyar, mai gyara na lura da shirin. A irin haka ne, a selection na mutum kwayoyi da kuma su dosages, da kuma magani ne da za'ayi a karkashin tsauraran likita dubawa. Babu dalilin da zai mai zaman kanta nada antiplatelet jamiái, saboda sakamakon na iya zama m.

Jerin contraindications:

• allergies.
• hemorrhagic diathesis.
• hadarin zub da jini;
• mai tsanani hanta da koda insufficiency.
• tarihi na arrhythmia.
• hauhawar jini, mai tsanani.
• obstructive cututtuka na numfashi tsarin.
• Yara shekaru (ga mafi kayayyakin).

Bugu da kari, mutane da yawa daga antiplatelet jamiái (jerin kayayyakin sake nazari a wannan labarin) suna contraindicated a lokacin daukar ciki da kuma lactation. A wannan lokacin, ya kamata a fi son kwayoyi da suke da hadari ga yaro da kuma ga mahaifiyarsa.

Antiplatelet jamiái. Kwayoyi: jerin ciki

Idan ka karya fetal wurare dabam dabam cikin hadarin na zubar da ciki. Wannan sabon abu ne da ake kira fetoplacental insufficiency. Idan ka karya da isar da oxygen zuwa jini da tayin tasowa tsanani hypoxia, wanda ya razana ba kawai bambancin sabon ci gaba, amma kuma mutuwa. Lokacin da diagnosing a Pathology na bukatar m magani, wadda ta ƙunshi a inganta jini ya kwarara, rage jini danko. Domin wannan kuma nada antiplatelet jamiái, duk da haka, sani cewa ba duk da kwayoyi a cikin wannan kungiyar ne hadari lokacin daukar ciki. Zai yiwu a yi amfani da kawai wasu daga cikin kudi.

"Kurantil"

Da miyagun ƙwayoyi ne Popular saboda gaskiyar cewa a cikin jerin contraindications babu ciki da kuma nono. Aiki sashi "chimes" - baya aka bayyana dipyridamole, wanda dilates jini da kuma damuarn thrombus samuwar. Yana inganta tsokar jini ya kwarara, tabbatar da isar da ake bukata adadin oxygen. A wannan hanya, K "Urantia" za a iya amfani da su a gaban zuciya da jijiyoyin jini cuta a cikin mata masu ciki. Duk da haka, babban nuni ga ciki shi ne placentofetal gazawar. By inganta rheological Properties na jini da kuma vasodilatation, rigakafin clogging tasoshin mahaifa, don haka da tayin ba da wahala daga hypoxia. A ci gaba da amfani da miyagun ƙwayoyi za a iya kira immunomodulating sakamako. Da miyagun ƙwayoyi stimulates samar da interferon, game da shi, rage hadarin kwayar cututtuka a cikin mahaifiyarsa. Ko da yake "Kurantil" kuma ana iya amfani da lokacin daukar ciki da kuma lactation, amma ya kamata kawai rubũta shi idan ya nuna. Duk da yake shan miyagun ƙwayoyi kamata rage amfani da shayi da kuma kofi a matsayin da suka rage ingancinta. Antiplatelet kwayoyi - kwayoyi (jerin sama) cewa ya kamata ba za a hada da irin wannan abin sha. Ko da yake ciki ba ya shawarci su don samun shiga a cikin kowace hanya.

Antiplatelet jamiái, a jerin kwayoyi wanda ya hada da dama daga sunaye, an yi amfani da yadda ya kamata a lura da cututtuka na zuciya da jijiyoyin jini tsarin. Duk da haka, lura da yiwu rikitarwa hade tare da rage jini danko da kuma clotting hanawa. Antiplatelet kwayoyi - kwayoyi da cewa za a iya amfani da kawai a karkashin kulawa da halartar likita, ya za karba dole sashi da kuma hanya na lura.