"Shirye-shirye" shiri: umarnin don amfani, sake dubawa

Shin Remicade yana da tasiri? Umurnai don amfani, sake duba magungunan wannan magani za a gabatar da su a kasa. Har ila yau, daga wannan labarin za ku koyi game da shari'ar da ake yi wa wannan miyagun ƙwayoyi, ko yana da contraindications da abubuwa masu ban sha'awa, abin da aka haɗa a cikin abubuwan da ke ciki da sauransu.

Form, abun da ke ciki

Maganin miyagun ƙwayoyi "Remicade" yana samuwa a cikin nau'i na lyophilized da aka nufa domin shiri na wani bayani jiko. Abinda yake aiki da wannan magani shine infliximab. Har ila yau, ya ƙunshi wasu kayan haɓaka a cikin nau'in polysorbate 80, sodium hydrogen phosphate dihydrate, sucrose da sodium dihydrogen phosphate monohydrate.

Abubuwan Abubuwa na asali

Menene magani mai mahimmanci? Umurnin yin amfani da shi yana cewa wannan wata matsala ne.

Shigar da jiki, likitan ya fara hulɗa tare da siffofin mai ƙwayar cuta na alpha (TNFa) mai soluble da transmembrane, ya rage aikin su ta wurin kafa wani tsari mai gina jiki.

Nazarin masanan sun nuna cewa abu mai amfani da miyagun ƙwayoyi ya rage karfin salula na mutum (inflammatory), kazalika da adadin alamun ƙwayoyin ƙwayar cuta a wuraren da aka shafa a gut. A cikin wannan yanayin, mai sauƙin warkarwa na mucosa na faruwa.

Pharmacokinetics na miyagun ƙwayoyi

Waɗanne sigogi na pharmacokinetic ne ke yin magani na Remicade? Umurnin, da sake dubawa sun nuna cewa an yi amfani da allurar rigakafi guda daya a cikin adadin har zuwa 20 MG / kg tare da karuwar haɓaka cikin iyakar ƙima.

Maimaita amfani da miyagun ƙwayoyi yana haifar da karamin abu mai aiki a cikin kwayar jini.

Hanyar yin amfani da wannan magani ba a ƙaddara ba.

Indiya don amfani

Menene manufar magani na Remicade? Amfani da wannan magani yana nuna a cikin lokuta masu zuwa:

• Rheumatoid arthritis a cikin tsari (idan magani na marasa lafiya da anti-inflammatory kwayoyi ba m). Ana gudanar da farfadowa a hade tare da Methotrexate. Wannan haɗin zai ba da damar rage alamun cutar, da kuma inganta yanayin gidajen abinci a matsayin cikakke.
• Crohn ta cutar a cikin marasa lafiya marasa lafiya. Ta yaya taimako na "Remicade" a wannan yanayin? Umurnin ya ce ya kamata ayi farfado da wannan magani tare da rashin haƙuri ko rashin aiki, kazalika da gaban maganin maganin ƙwayoyi ga magungunan ƙwayoyi. Tare da wannan ganewar asali, "Remicade yana taimakawa wajen kawar da duk alamun cutar, kula da gyarawa da kuma warkar da cututtuka da sauri, kusa da fistulas da kuma inganta yanayin marasa lafiya.
• Ciwon Crohn a matasan. Yin jiyya tare da wannan miyagun ƙwayoyi yana aikata tare da rashin haƙuri ko rashin aiki, da kuma a gaban kasancewar contraindications zuwa tsarin daidaita farfadowa. Miyagun ƙwayar cuta yana rage alamar cutar ta cutar, tana tallafawa gafara kuma inganta yanayin rayuwar marasa lafiya.
• Ciwon gwiwoyi ne a cikin manya. Magungunan miyagun kwayoyi "Remicade", wadanda aka gabatar da su a ƙasa, an tsara shi a yayin da al'ada ba ta da amfani. Yin jiyya da wannan miyagun ƙwayoyi yana taimaka wajen rage alamun cutar, warkar da mucosa na hanji, rage maganin ko warware GCS. Ya kamata a lura cewa bayan da aka sanya wannan magani babu bukatar mai haƙuri ya zauna a asibiti.
• Ciwon cututtuka ne a cikin yara. Yin magani tare da wannan miyagun ƙwayoyi ne aka ba da izini ga yara masu shekaru 6 zuwa 18, a yayin da al'amuran al'ada suka tabbatar da rashin tasiri.
• Ankylosing spondylitis (idan misali farfado ba m). Ta yaya taimakon taimako na Remicade tare da wannan ganewar asali? Umarni don yin amfani da rahotanni cewa wannan kayan aiki ya rage alamar cutar da cutar kuma ya inganta ɗakunan.
• Psoriasis (tare da matakan daidaitawa). Ta yaya taimakon "Remicade" tare da psoriasis? Masana sun ce wannan miyagun ƙwayoyi yana rage yanayin ƙin ƙwayoyin cuta a kan fata kuma yana daidaita tsarin tafiyar da keratinocyte.
• Arthritis ne psoriatic (tare da m misali farfado). Magunguna "Remicade" an tsara su tare da "Methotrexate" ko kuma a matsayin kwayar halitta a gaban kasancewar contraindications ko rashin haƙuri na karshen. A sakamakon magani, alamun cututtuka na rage arthritis, aikin aikin marasa lafiya ya inganta, da kuma girman cigaba na radiologic a cikin ƙwayar polyarthritis psoriatic.

Contraindications

An haramta jiyya tare da "Remicade" lokacin da:

• mai tsanani dauke da kwayar cutar tsari (msl, sepsis, ƙurji, da tarin fuka, opportunistic cututtuka) .
• Ƙara yawan hankali ga mai haƙuri zuwa infliximab, da kuma nau'o'in sunadarai da kuma wasu kayan aikin miyagun ƙwayoyi;
• Yawan shekaru har zuwa shekaru 6 (tare da cututtuka da cututtuka da kuma Crohn);
• Hanyar ciki;
• Zuciyar zuciya;
• A karkashin shekaru 18;
• A matsanancin ciyarwa.

Gyara: umarnin don amfani. Kuma inda za a shiga (kawai a asibiti)?

Dole ne a yi amfani da miyagun ƙwayoyi ne kawai a ƙarƙashin kulawa da wani gwani (wato, a asibiti), wanda ke da kwarewa sosai wajen bincikar cutar da kuma samu nasarar magance cututtuka na sama.

Ana maganin maganin a cikin intravenously na minti 120. A lokaci guda, gudun kada ya wuce 2 ml a minti daya. Dole ne a aiwatar da hanyoyin tare da yin amfani da tsarin jiko.

Sashin maganin miyagun ƙwayoyi ya dogara da alamun.

Rheumatoid arthritis

Da wannan ganewar asali, ƙaddarar farko zai kasance 3 MG kowace kilogiram. An sake amfani da magani bayan makonni 3-6. Sa'an nan ana amfani dashi kowane wata biyu.

Idan ba'a samu sakamako na warkewa ba, la'akari da batun fitowar farfadowa.

Yawancin lokaci da miyagun ƙwayoyi ne "Remicade" tare da rheumatoid amosanin gabbai gudanar tare da "methotrexate".

Ulcerative colitis

Sanya na farko tare da wannan ganewar shine 5 MG kowace kilogiram na nauyin jiki. A daidai wannan nau'i, ana amfani da miyagun ƙwayoyi bayan makonni 3-6. Sa'an nan kuma ana gudanar da magani a kowane watanni biyu.

Idan ya cancanta, ana iya ƙara kashi zuwa 10 MG kowace kg. Ana lura da sakamakon farillar a cikin makonni 14. Idan ya kasance babu, ya kamata ku ci gaba da kulawa.

Psoriatic arthritis

Tare da cututtukan cututtuka na psoriatic, an yi amfani da miyagun ƙwayoyi "Remicade" a cikin kashi na farko na 5 MG kowace kg. An sake amfani da magani bayan makonni 3-6. Sa'an nan ana amfani dashi kowane mako bakwai.

Zaka iya rubuta magani a hade tare da Methotrexate.

Crohn ta cutar

Tare da wannan ganewar asali, kwayoyin da aka yi daidai da 5 MG da kg ana nuna su ga manya. Idan ba a samu sakamako na asibiti a cikin makonni 2 ba, an soke miyagun ƙwayoyi.

Tare da sakamako mai kyau na miyagun ƙwayoyi, wadannan makircinsu na yiwuwa:

• Ana gudanar da maganin a daidai wannan kashi kamar yadda aka yi a farkon jiko, bayan kuma ana amfani da makonni 3-6 akai-akai. Bayan haka, ana aiwatar da injections kowane watanni biyu. Idan an buƙata, ana iya ƙara sashi zuwa 10 MG kowace kg.
• Ana amfani da magani ne kawai idan an sake dawowa, idan ba a wuce makonni 16 ba bayan ya fara amfani.

Kwayar Crohn a kananan yara

Kwayar Crohn na matsanancin matsayi ko mai tsanani a cikin yara a ƙarƙashin 18 ya nuna kashi na farko na 5 MG kowace kilogiram. Dole a fara yin gyare-gyare bayan 3-6 makonni. Sa'an nan ana amfani da magani kowace watanni biyu Idan an buƙata, an gyara sashi zuwa 10 MG kowace kg.

A matsayinka na mulkin, irin wannan magani an hade tare da immunomodulators na 6-mercaptopurine, "Azathioprine" ko "Methotrexate". Idan ba a cimma sakamako na asibiti ba (na makonni 10-11), to, yin amfani da miyagun ƙwayoyi ba a so.

Cutar Crohn tare da fistulas

Kashi guda ɗaya na miyagun ƙwayoyi tare da wannan ganewar shine 5 MG kowace kg (a cikin manya). An sake amfani da magani bayan makonni 3-6. Idan magungunan maganin warkewa bayan 3 injections ba a kiyaye su, to, karin magani ba shi da amfani.

Tare da sakamako mai kyau na miyagun ƙwayoyi waɗannan makircinsu zasu yiwu:

• Bayanin sakewa bayan makonni 3-6, sannan kowane watanni biyu;
• An yi amfani da magani idan ya sake komawa idan kasa da makonni 16 ya shuɗe.

Ankylosing spondylitis

Yaya aka yi amfani da magani na Remikade tare da wannan ganewar asali? Umurnin yin amfani da ita ya nuna cewa da wannan cuta, asalin magungunan miyagun ƙwayoyi ya zama 5 MG kowace kg. Bayan wannan, ana amfani da miyagun ƙwayoyi bayan makonni 3-6.

Jiyya bai kamata ci gaba ba idan ba a lura da sakamako ba don watanni daya da rabi.

Psoriasis

A lura da psoriasis, maganin farko na miyagun ƙwayoyi ne 5 MG kowace kilogiram. An yi amfani da miyagun ƙwayoyi akai-akai bayan makonni 3-6, sannan kowane mako takwas.

Hanyar shirya wani bayani ga infusions

Dole ne a shirya matsala bisa ga tsarin da aka tsara:

• An yi amfani da kashi da adadin vials.
• An shayar da magani a cikin lita 10 na ruwa ta amfani da sirinji. Don yin wannan, cire murfin (filastik) daga kwalba mai yalwa da shafa goge tare da barasa. An gabatar da allurar ta wurin cibiyarta, kuma ana sarrafa ruwa a kan bango.
• Maganin da aka haɗuwa sosai (ƙungiyoyi masu juyawa) har sai foda ya rushe. Dole ne miyagun ƙwayoyi ya zama marar launi ko rawaya. Idan kumfa ya kasance a yayin haɗuwa, dole ne a dakatar da maganin na tsawon minti 5. Sakamakon kwaskwarima mai kwakwalwa zai iya kasancewa a cikin samfurin gama.
• An daidaita yawan yawan miyagun ƙwayoyi tare da bayani na sodium chloride (0.9%) har zuwa 250 ml. Don yin wannan, an saka ruwan da aka shirya a kwalban, inda sodium chloride ya riga ya ƙunshe. Dukkanin kayan haɓaka suna haɗuwa sosai.
• Ana shirya wannan shirye-shiryen ba bayan kwanaki uku bayan shiri na maganin miyagun ƙwayoyi.

An hana yin magani tare da sauran wakilai ta hanyar wannan tsarin. Idan a cikin bayani akwai wasu ƙananan haɓaka ko ƙananan ƙwayoyin, to ba'a ba da shawarar yin amfani da shi ba.

Dole ne a zubar da yawancin miyagun ƙwayoyi.

Hanyoyin Gaba

Lokacin amfani da kwayoyi, wadannan halayen halayen zasu yiwu:

• Rashin hankali, rashin tausayi, ƙara damuwa, damuwa, damuwa, rashin tausayi, amnesia, psychosis, ciwon kai;
• Harshen kwakwalwa, sinusitis, bronchospasm, dyspnea, rashin lafiyan halayen, ciwon huhu, zubar da jini, ƙwayar cutar, ƙwaƙwalwa;
• Conjunctivitis, keratoconjunctivitis, endophthalmitis;
• Edema da cututtukan urinary;
• Tidal disorders na na jiki wurare, bradycardia, ecchymosis, hematoma, vasospasm, syncope, palpitation, cyanosis, petechiae, arrhythmia;
• Thrombocytopenia, anemia, neutrocytopenia, leukocytopenia, lymphocytopenia, lymphadenopathy, lymphocytosis;
• Cheilitis, maƙarƙashiya, cholecystitis, reflux, diverticulitis, zawo, tashin zuciya, nakasa, aikin hanta hanta;
• Skin rash, bushe fata, alopecia, seborrhea, skin skin, furunculosis, urticaria, ƙãra sweating, dermatitis naman gwari, warts, hyperkeratosis, erysipelas, fata pigmentation cuta, bullous rash.

Bayani game da miyagun ƙwayoyi

Yanzu ku san yadda za ku yi amfani da miyagun ƙwayoyi "Remicade". An bayyana umarnin yin amfani da magani a sama.

A mafi yawan lokuta, wakili a cikin tambaya yana aiki tare da aikin. Saboda haka, gwagwarmaya daga marasa lafiya sunfi dacewa. Mutane da suke yin amfani da wannan rahoton cewa bayan an allura su kusan kusan sun tafi. Duk da haka, wasu marasa lafiya suna jin tsoron jaraba, wanda zai iya haifar.