Fluticasone furoate: umarnin don amfani, analogs da kuma sake dubawa

Domin lura da kumburi tafiyar matakai abin da ke faruwa a jikin mutum a duka biyu m da kullum form, da ake amfani da dama iri kwayoyi. Wasu suna nonsteroidal yanayi, wasu suna tsaye alaka ji ba gani.

A miyagun ƙwayoyi ya shafa?

A karshen kungiyar da kwayoyi da yadda ya kamata mu bi kumburi, yana nufin flukatikazona furoate. Triftorirovannoe Wannan fili aka shirya synthetically. By da yanayi, da abu nasa ne da rukuni na hormones glucocorticoids. Drug bangaren yana da isasshe furta anti-mai kumburi sakamako. Samun wani babban matakin affinitivnosti zuwa glucocorticoid rabe, shi rinjayar daban-daban na Kwayoyin, kamar macrophages, lymphocytes, eosinophils, da sauransu. Har ila yau batun rinjayar kumburi shiga tsakani, wato, chemokines da cytokines.

Yadda za a shigar da jiki?

A peculiarity wannan halitta ne cewa flukatikazona furoate ba za a iya tunawa da cikakken by jiki an metabolized da hanta. Saboda haka, abu ne halin da rauni na tsari mai daukan hotuna.

Akwai da wadannan siffofin da yin amfani da miyagun ƙwayoyi:

• Intranasal gwamnati. Tare da wannan hanya na lura da miyagun ƙwayoyi da ta bioavailability dogara a kan sashi. Idan shan nufin 110 micrograms da rana, da abun ciki a cikin jini ba a zahiri gano. A cikin hali na shan miyagun ƙwayoyi, a wani sashi na 880 MG sau uku da 24 hours, ta bioavailability ya 0.5%.
• Idan ka dauki flukatikazona furoate inhalation, shi ne wani nuna alama na ta bioavailability ya 27,3%.

Har ila yau, da miyagun ƙwayoyi za a iya dauka da baki da kuma intravenously.

Wannan magani ta ɗaure da jini sunadaran da index of 99% ko fiye. Kuma ya reacts tare da ja da maikacin jini ne negligible. Flukatikazona furoate quite yadda ya kamata metabolized a cikin hanta da kuma enzymatically cleaved to m abubuwa kira fluticasone. Wannan magani ne in mun gwada hanzari bar cikin jini. Idan magani ake dauka baki ko intravenously, shi ne kusan gaba daya cire daga bile daga hanji da kuma wani infinitesimal kashi excreted da kodan.

shaidar

Fluticasone furoate, da wa'azi ga wanda dole tafiya tare da kunshin na magani, da aka nuna a cikin wadannan cututtuka:

• Shekara-zagaye rashin lafiyan rhinitis hali.
• Obstructive na huhu cuta, ciki har kullum.
• Bronchial fuka - kamar yadda tabbatarwa na hada magani.

Idan kana da wani fayyace syndromes, wanda aka bayyana a sama, da kayayyakin bisa wannan aiki sashi iya yadda ya kamata magance su. Amma kar ka manta da cewa muhimmiyar hujja game da fluticasone furoate, wanda shi ne mai hormone. Sanya irin wannan magani iya kawai your likita.

contraindications

Wannan pharmaceutical samfurin yana da yawan contraindications da kuma hani akan yin amfani. Yana ba za a iya dauka a cikin wadannan lokuta:

• Hypersensitivity da babban aiki sashi.
• Yara a karkashin shekaru 18 (ba tare da wani musamman likita ta shawarwarin).

A iyakance abubuwan da liyafar da wannan magani zai iya zama:

• Hanta tabarbarewa.
• Na huhu da tarin fuka.
• Cututtuka ba su warke gaba daya, ko a kullum form.

Game da matsayi na ko yana yiwuwa a gare ciki da kuma lactating mata, fluticasone furoate, umarnin don yin amfani da nuna cewa wannan bayani ne bai isa ba. Wannan magani ya kamata a yi amfani ne kawai a lokuta inda hadarin da tayin ko wani yaro a kasa da sa ran tabbatacce sakamakon zuwa ga uwar.

illa

The umarnin don yin amfani da nuna wani fairly m gefen sakamakon wannan miyagun ƙwayoyi, wanda ya dogara a kan iri-iri na ta aikace-aikace. Intranasal amfani da miyagun ƙwayoyi, suna bayyana kamar haka:

• Munanan a cikin numfashi tsarin: hanci zub da jini, ya bayyanar a kan mucosal ulcers.
• Rashin lafiyan halayen: kurji a jiki, angioedema, anaphylaxis, urticaria.

Idan fluticasone furoate, wanda sake bitar kagaggun tabbatacce, yana amfani a cikin nau'i na inhalation na hade-type shirye-shirye, da wadannan illa iya faruwa:

• Cututtuka dauke da kwayar cutar hali: mura, ciwon huhu, mashako da kuma sauran irin wannan mamaki daga cikin manya na numfashi fili. Yana iya kuma ci gaba oropharyngeal candidiasis.
• Disturbances a cikin al'ada aiki na numfashi tsarin, wanda za a iya bayyana a cikin nau'i na oropharyngeal zafi, nasopharyngitis, sinusitis, pharyngitis, tari, dysphonia, da kuma sinusitis.
• Cututtuka na connective kuma kwarangwal tsoka nama: samu karaya, arthralgia, zafi a baya.
• Zaka kuma iya samun ciwon mara, migraines, febrile mamaki, beats, glaucoma, rage kashi yawa, tawayar aiki na hypothalamus-pituitary-adrenal tsarin, tsumburai girma a cikin yara da kuma matasa, cataract.

Yaya za a nemi da nawa?

Fesa "Fluticasone furoate" za a iya dauka intranasally sau daya a lokacin da rana. Har ila yau, da miyagun ƙwayoyi za a iya amfani da inhalation a hade shirye-shirye. A sashi na magani an wajabta, dangane da haƙuri da shekaru daga 27.5 zuwa 55 mcg. Don kula da wajabta taro na aiki abu 27.5 MG na cikin shirye-shiryen.

Masana'antun na pharmaceutical kayayyakin sun yi gargadin cewa a lokacin jiyya da miyagun ƙwayoyi ya yi da hankali a kan aiwatar da ayyukan da hadarin m. Wadannan sun hada da ayyuka da cewa bukatar kulawa ta musamman da kuma azumi psychomotor halayen, kamar tuki wani abin hawa ko aiki da injuna.

miyagun ƙwayoyi interactions

Idan concomitant amfani da fluticasone furoate ketoconazole shawarar taka tsantsan.

Kuma ba da shawarar for lokaci daya co-gwamnati tare da "ritonavir". Wannan shi ne saboda hadarin da karfafa tsari fluticasone furoate.

yawan abin sama

A binciken da miyagun ƙwayoyi abu yiwuwa data yawan abin sama marasa lafiya samu wani kashi wanda ya wuce da shawarar 24 sau, a kan lokaci tsawon fiye da kwanaki 3. A sakamakon haka, babu hujjar da m tsari manifestations. Amma da miyagun ƙwayoyi masana'antun sun yi gargadin cewa mataki na glucocorticoids iya samun ci gaba. A wannan halin da ake ciki akwai bukatar for likita dubawa da kuma dace magani dangane da bayyanar cututtuka.

shirye-shirye

A cikin kasuwar akwai 'yan pharmaceutical kayayyakin magunguna, da babban aiki sashi na wanda fluticasone furoate "Avamys", "Flutisan", "Nazofan", "Flutineks", "Seroflo", "Flohal" da "Fleksonaze". A mafi popolyarnym nufin da wannan layi ne na farko mai suna wakili. "Avamys" fluticasone furoate qunshi a matsayin babban aiki sashi da kuma samuwa ne a wani m SPRAY.

"Avamys"

Wannan kayan aiki ya tabbatar da kanta tare da mafi kyau gefen da magani daga rashin lafiyan rhinitis. A wannan cuta, akwai ba kawai busa na hanci mucosa da profuse sallama gare ta, amma kuma a cikin nau'i na ocular bayyananen tearing, itching, redness da m majiyai "yashi". Wannan muhimmanci rage bayyanar cututtuka da ingancin rayuwar yau da kullum, shi yana da mummunan tasiri a kan ta dace da kuma kaiwa zuwa gagarumin bayar wa a far. Masana kimiyya sun gano cewa, babban dalilin rashin lafiyan bayyananen hidima zumudi parasympathetic jijiyoyi da cewa kawo kumburi shiga tsakani mucosa na sinuses. Tare da duk bayyanar cututtuka na rashin lafiyan rhinitis copes miyagun ƙwayoyi "Avamys." Fluticasone furoate, kunshe a abun da ke ciki kamar yadda wani babban aiki sashi, abubuwa a kan aiki shafukan analyzers rabe cewa toshe a sakamakon jikin mutum ta dauki ga allergens. Saboda haka, duk m, kuma ko da m bayyanar cututtuka bace da kuma haƙuri da ingancin rayuwa da aka muhimmanci inganta. Saboda gaskiya cewa, babban bangaren yana da babban dangantaka zuwa rabe, da connection zama sosai robust da kuma m, wanda ya samar da zaunanniya sakamako daga cikin shirye-shiryen.

All contraindications da kuma gefen sakamakon da miyagun ƙwayoyi ne kai tsaye alaka da gaskiyar cewa aiki abu na nufin "Avamys" - fluticasone furoate, umarnin ga wanda aka bai wa a sama. Ta yayi kashedin cewa hormonal pharmaceutical samfurin ba za a iya dauka ba tare da wani likita ta sayen magani.

hade kayayyakin

Takzhedlya magani na rashin lafiyan rhinitis, COPD da Bronchial fuka Aiwatar hada shirye-shirye dauke da fluticasone furoate, vilanterol da kuma wasu karin aka gyara. Mafi shahara a cikin kasar ne kamar magani "Relvar Ellippta". Wannan pharmaceutical samfurin yana dauke da aiki sinadaran a cikin wadannan yawa da kashi:

• Micronised fluticasone furoate, 100 mcg.
• Vilanterola trifenatat micronized 40 g.

Wannan magani zo a cikin wani nau'i na metered foda ga inhalation. Yana yana da wani furta anti-mai kumburi da bronchodilator effects. "Relvar Ellippta" yana nufin nufin ciwon bronchodilator sakamako, saboda aiki sinadaran ne hubbub: a zabe beta-2-agonists, da kuma gida glucocorticosteroid.

Bisa ga shaidar miyagun ƙwayoyi jiyya ne:

• Bronchial fuka, a cikin abin da nufin amfani da shi don tabbatarwa far.
• Obstructive na huhu cuta a cikin kullum form (COPD). A wannan yanayin, da ganewar asali daga miyagun ƙwayoyi jiyya iya rage exacerbations.

Aka bayyana miyagun ƙwayoyi ne aka yi nufi kawai ga inhalation cewa an samar da zarar kowace rana a wani lokaci (da yamma, ko da safe). Masana'antun bayar da shawarar cewa bayan hanya, kurkura bakin da ruwa, amma kada hadiye shi.

Marasa lafiya da asma da ya dauki da miyagun ƙwayoyi, ko da kuwa da kasancewar pronounced cutar bayyanar cututtuka. Idan ɗan hutu tsakanin darussa na magani a can ne bayyananne manifestations da cutar, likita yawanci nada da beta _2-agonists short mataki a cikin nau'i na inhalations. Sashi ance kawai da halartar likita.

Wadannan yawa na aiki sinadaran (vilanterola trifenatat da flukatizona furotat daidai da) za a iya sanya wa manya da yara a kan shekaru 12 a daya inhalation / 1 lokaci kowace rana:

• 22 g + 92 g;
• 22 .mu.g + 184 MG.

A farko kashi da aka sanya likita ga waɗanda marasa lafiya da suke bukatar low zuwa matsakaici yawa na aiki abubuwa, kazalika da magani daga COPD a manya. Ya kamata a lura da cewa, domin lura da kullum huhu toshewa a yara ba m. A wannan sashi wajabta mutane da hanta cuta a sama wa talakawan.

Nau'i na biyu na sashi wajabta wa marasa lafiya da suke bukatar hakan taro na aiki abubuwa da magani daga fuka, a lokacin da mafi ƙarancin sashi ba exert da ake so sakamako.

Mutane fiye da shekaru 65 da haihuwa, kazalika da wa anda suke da cuta da kodan, a gyara daga cikin miyagun ƙwayoyi ba bukatar.

Don amfani da wannan magani a cikin kunshin yana da wani musamman inhaler wanda yana da nuances na aiki da kuma goyon baya. Suna aka bayyana a cikin daki-daki, a cikin umarnin kafin amfani da ake bukata, don su bincika summary hankali.

Side effects da miyagun ƙwayoyi iya bayyana a cikin wadannan siffofin:

• Popular sau da yawa: manya na numfashi fili kamuwa da cuta, mura, oropharyngeal candidiasis, ciwon huhu. migraine. arrythmia. nasopharyngitis, sinusitis, rhinitis, hoarseness, tari. ciki zafi. samu karaya, arthralgia, zafi a cikin mayar da; zazzaɓi.
• Lokaci-lokaci ci karo: hypersensitivity, rash, angioedema, urticaria, anaphylaxis. tashin hankali cuta. tsãwa; tachycardia.

Contraindications ga yin amfani da "Relvar Ellippta" su ne:

• Rashin lafiyan madara gina jiki ko a kan wani bangaren na miyagun ƙwayoyi.
• Yara har zuwa shekaru 12 years.

Tare da kula da pharmaceutical samfurin ya kamata a dauka a marasa lafiya tare da zuciya da jijiyoyin jini cututtuka osudistymi mai tsanani, tare da na huhu da tarin fuka da kuma na kullum cututtuka.

Mata masu ciki da ke wajabta da miyagun ƙwayoyi ne kawai a lokuta lokacin da tambaya game da amfanin da uwa tasa, ta fi hadarin da tayin. Lokacin da lactation da magani gudanar a tare da tare da abandonment na nono da kuma hadarin kawar da yaro.

The hadin gwiwa da yin amfani da miyagun ƙwayoyi "Relvar Ellippta" tare da beta-blockers kamata a kauce masa, sai dai inda cikakken zama dole. Shi ne ma daraja da hankali a hade tare da "Ketoconazole" da "ritonavir".

analogs

Idan lura da rashin lafiyan rhinitis, COPD ko asma, za ka iya ba za a sanya wa fluticasone furoate, analogs wannan magani zai iya zama wani m madadin. Kulawar lafiya naka dangane da mutum halaye da kwayoyin, rubũta da dama miyagun ƙwayoyi. Daga cikin analogues da miyagun ƙwayoyi sun hada da:

• "Asmaneks".
• "Aurobin".
• "Garazon".
• "Deksapos".
• "Karizon".
• "Abistan".
• "Beklat" da kuma wasu sauran magunguna da cewa ya kasance a cikin wannan pharmaceutical kungiyar tare da flukatizona furotatom.

Kada ka manta da cewa magunguna ya kamata a dauka kawai a kan takardar sayen magani, da kuma kawai bayan nazarin da umarnin.