Statins - abin da yake da shi? Statins (kwayoyi): sunan

Statins - kwayoyi da cewa za a iya gudanar kawai likita da kawai bayan jerin jini gwaje-gwaje da cewa sanin matakan cholesterol. A irin haka ne, su Babban burin - kare zuciya da jijiyoyin jini tsarin daga cutar da kuma samu pathologies. Lokacin danganci likita zamar masa dole ya ba da shawara da mãsu haƙuri a kan wadannan abubuwa:

• statins - abin da shi ne;
• hadaddun illa daga magani.

Har ila yau, likita zai gudanar da wani tattaunawar a kan topic cewa statins ya kamata a dauka kullum. Kawai a karkashin wannan yanayin, da suka gaske kare zuciya da jini, kuma dole a furta warkewa sakamako.

A ra'ayi na cholesterol

Cholesterol - a sia ciwon halitta asalin: 80 bisa dari da aka hada da hanta, da kuma 20 da aka ingested da abinci. cholesterol rawa a cikin dace aiki na jiki ne quite muhimmanci: shi ne daya daga cikin kayan gini a salon salula matakin, activates metabolism, kare Kwayoyin daga kufan korau abubuwan da hannu a cikin ci gaban da bile acid da kuma jima'i ji ba gani. Cholesterol ne "mai kyau" da "mara kyau". Kuma daga likita ra'ayi, wannan rarrabuwa ne kamar haka:

• HDL - high yawa lipoproteins. Mutane da wani babban abun ciki na cholesterol a cikin jini ba yiwuwa ga zuciya cuta. Rarar HDL cholesterol ne hawa mayar da hanta, inda shi wuce da kira, saboda haka ba za su cholesterol plaques da bai gabatar da wata barazana ga kiwon lafiya. A wannan yanayin, statin far ba a bukata, saboda jiki a guje smoothly da kuma daidaituwa.
• LDL - low-yawa lipoproteins. Babban hadari ga kwayoyin suna a lokacin da aka haɗa zuwa cholesterol plaques. Mene ne hatsarin
  sabon abu? Atherosclerotic adibas wanda shirya a cikin jirgin ruwa (a kan garun), sanƙarar su, ta haka ne impairing jini ya kwarara. Wannan take kaiwa zuwa hypoxia, bugun jini, ciwon zuciya.

Statins - abin da yake da shi?

A karni na ashirin atherosclerosis aka gane a matsayin daya daga cikin manyan Sanadin mutuwa, domin shi ne hanyar tsokar zuciya infarction da kuma bugun jini. Na dogon lokaci shi ne erroneous ra'ayi na likitoci da cewa atherosclerosis - shi ne babu ja da jiki ta halitta tsufa tsari. A gano statins ya juyin juya hali a cikin likita duniya: suna da wani iko holesterinsnizhayuschim dukiya. A sakamakon nazarin da za'ayi a cikin shekaru 5, sun wadannan Manuniya:

• Raguwa a LDL cholesterol (bad cholesterol) da 35%.
• Kara matakin HDL (mai kyau cholesterol) 8%.
• Akan rage bugun jini da kashi 30% da kuma zuciya harin da 42%.

Statin kwayoyi - kwayoyi da ta hanzarta da kuma tsara da kira na cholesterol a cikin jiki, rage taro da inhibiting MMC-CoA reductase.

Don rubũta statins

A cewar nazarin, bayan shan kwayoyi da aka lura da kyau kuzarin kawo cikas a marasa lafiya da na kullum jijiyoyin zuciya da cututtukan zuciya. Evidence cewa tabbatacce sakamakon statin far a sauran pathologies da cututtuka zama, babu. Amma wadannan kayan aikin ba kawai warkewa amma kuma m. Tun statins - kwayoyi da rage cholesterol, suna sanya wa mutane na zuwa wadannan Categories:

• Mutane da homozygous iyalinmu hypercholesterolemia, wanda ba amenable don magani da hypolipidemic kwayoyi.
• Marasa lafiya fama da ischemic cututtukan zuciya, ko da kuwa cholesterol matakin.
• Marasa lafiya da suka sha wahala a zuciya da kuma angina pectoris.
• Marasa lafiya da jijiyoyin zuciya ciwo.
• Masu ciwon sukari don sarrafa jini cholesterol matakai.
• Marasa lafiya fama da muhimmanci hauhawar jini a hadarin cututtukan zuciya.
• Marasa lafiya fama da atherosclerotic jijiyoyin bugun gini raunuka. Irin cututtuka sun hada da atherosclerosis na cerebral tasoshin ƙananan wata gabar jiki, da koda arteries da kuma gaban atherosclerotic plaques a carotid jijiya.
• Mutane masu ba wahala daga zuciya da jijiyoyin jini cututtuka, amma tare da high matakan da cholesterol a cikin jini.

Statins - kwayoyi da cewa suna daga cikin mafi kyau wajen rigakafin a yaki da cututtuka na zuciya da jijiyoyin jini tsarin. Bisa kididdigar da, a} asashen da kara tallace-tallace na wadannan kwayoyi, da mace-mace kudi daga cututtuka hade tare da high cholesterol matakai a cikin jini ƙwarai rage.

"Ga" da "da"

Saboda haka statins. Mẽne ne da kuma yadda ake bukata - mun gani a sama. Amma likitoci ra'ayi game da wadannan kwayoyi ne shubuha. Akwai m "ga" da "da" tare da girmamawa ga wadannan kwayoyi. Duk da cewa talla taken alkawari don kawar da yawan atherosclerosis da kuma duk wannan yana nuna cuta, statins ba ko da yaushe, kuma ba su da wani amfani har. Musamman rigima ne tambaya na lokacin su ne mazan mutane: da farko, statins - kwayoyi, ga wanda Farashin ne m ga dukkan; Na biyu, illa iya haifar da mafi zãlunci daga mai kyau a lokacin da shan kwayoyi kamar yadda prophylaxis. Bisa ga sakamakon da gwajinsu gudanar da daban-daban cibiyoyin, masana sun ce da wadannan:

• A amfani da statins matsayin m gwargwado, rage hadarin ciwon zuciya ko bugun jini, lalle ne m, amma illa suna tilasta likitoci tunani kafin ka sanya su zuwa marasa lafiya da suke yi ba a baya fuskantar da cutar zuciya.
• Musamman a hankali rubũta statins ga mutãne waɗanda suke cataract bayyanar cututtuka ko riga fama da cutar. Bisa kididdigar da, gwamnatin da kwayoyi na kara hadarin cataracts da 52%.
• Wannan kuma ya shafi tsofaffi mutane fama da ciwon sukari. Statin far stimulates da ci gaban cataracts a 5.6 sau sauri.

Amma, duk da haka, da sabuwar statin kwayoyi amfani a likita yi karin da kuma kawo nasu amfani. An gogaggen likita, dole shawara da haƙuri kafin ka rubũta lura da wadannan kwayoyi, a kan al'amurran da suka shafi wadannan:

• Statins - abin da yake da shi?
• Me ya sa ran daga shan kwayoyi: galaba magani da kuma rigakafin.
• Side effects kuma sakamakon da miyagun ƙwayoyi.
• Kamar yadda a cikin abin da allurai dauki miyagun ƙwayoyi.

Statins da cholesterol: da jefa gefen

Magani ragewan cholesterol matakai a cikin jini sakamakon a wani canji na sauran Manuniya a cikin jiki:

• Statins rage samar da ba kawai cholesterol, amma kuma da wanda ya riga - mevalonate. Shi ne tushen da yawa muhimmanci abubuwa da yin nazarin halittu ayyuka a cikin jiki. A hasara daga cikin wadannan abubuwa za su iya kai wa ga sauran cututtuka.
• A low cholesterol matakan iya zama mafi cutarwa fiye da high: shi take kaiwa zuwa ƙãra hadarin ciwon daji, anemia, cuta na cikin juyayi tsarin da hanta.
• Kamar yadda bincike ya gudanar a Amurka, ta ƙara matakan cholesterol jawo wani low magnesium abun ciki a cikin jiki. Its karanci take kaiwa zuwa angina, hauhawar jini, da ciwon sukari da kuma ci gaban arrhythmias.
• "Bad" cholesterol ne rayayye da hannu a nama gyara a salon salula matakin. Statins iya hana wannan aiki, abu don myalgia (wani rauni, edema, tsoka zafi) da kuma ko da murdede dystrophy.

illa

Damage statins a su bayyana dogon liyafar gefen irin mamaki:

• Rashin lafiyan halayen: itching, fata na gaggawa, urticaria, anaphylaxis, erythema multiforme, Lyell ta ciwo.
• Tsarin narkewa kamar: zawo, tashin zuciya da amai, hepatitis, pancreatitis, jaundice.
• Gawan hematopoiesis: thrombocytopenia.
• Juyayi tsarin: dizziness, paresthesia, ɓacin hankali, na gefe neuropathy, malaise, wani rauni.
• Musculoskeletal tsarin: cramps, ciwon baya, amosanin gabbai, myiasis.
• Metabolism: hypoglycaemia (karu a jini sugar), da hadarin da ciwon sukari.

Dogon lokacin da yin amfani da statins iya kai wa ga rashin barci, ciwon kai, rashin ƙarfi, nauyi riba ko anorexia.

Wasu ka'idojin da statin zabi

Idan, bayan duk "ribobi" da "da" shawarar da aka sanya don sanya wani statin, shi ne ya cancanci a duba wasu daga cikin siffofin: karfinsu da sauran kwayoyi da kuma gaban kullum cututtuka.

• Statin far da magunguna ga gout, da ciwon sukari da kuma hawan jini zai iya sa hadarin myopathy sau biyu.
• A kullum hanta cututtuka da ya dauki magunguna tare da ƙarin tsaro fasali. Wannan low kashi rosuvastatin da pravastatin ( "Pravaksol"). Tare da su aka tsananin haramta dauki maganin rigakafi da kuma barasa.
• A m zafi a cikin tsokoki ko a lokacin motsa jiki, da cewa zai iya fararwa lalacewar tsoka nama, shi ne bu mai kyau ya dauki pravastatin.
• Tare da matsananci hankali rubũta kwayoyi ga marasa lafiya da na kullum koda cuta. Babu shakka ba zai iya yin amfani da guba domin kodan statins: suna fluvastatin magunguna - "Lescol forte", atorvastatin - "Lipitor."

Idan manufar samun wani statin - a cholesterol-ragewan low yawa, su za a iya amfani da a hade tare da nicotinic acid. Ideal jamiái hada rosuvastatin ko atorvastatin.

The kowa rarrabuwa na statins

Game da su aiki don rage cholesterol statins kasu kashi 6 kungiyoyin:

Statins (sunan kayayyakin da muka lissafa a kasa) aka zaba da kuma nada da likita, dangane da matakin da cholesterol a cikin jini.

rosuvastatin

A talakawan kullum sashi ne 5-10 MG na rosuvastatin. Domin tsanani da rashin lafiya marasa lafiya da magani daga iyalinmu hypercholesterolemia, a kullum kashi na har zuwa 40 MG. Shi ne ma da matsakaicin. Roba miyagun ƙwayoyi.

pravastatin

Pravastatin kullum rate - shi ne 20-40 MG. Matsakaicin jure kashi (80 MG) da aka ba amfani saboda bai cika bincika mataki. Semi-roba miyagun ƙwayoyi.

atorvastatin

Atorvastatin - roba miyagun ƙwayoyi tsara ta uku. Daga ƙarni na statins ne mafi tasiri, misali, ya wuce yadda ya dace da fluvastatin rabin. Harufan far da shawarar 10-20 MG da rana. A cikin rashi na so sakamako na da sashi ne ta ƙara zuwa 40 MG da rana. Atorvastatin amfani da sashi na 80 MG da rana domin lura da marasa lafiya da m jijiyoyin zuciya ciwo. Roba miyagun ƙwayoyi.

simvastatin

Simvastatin yana da magani ne mai yaduwa wanda yake da sauƙi a matsayin lovastatin. Farawa na yau da kullum shine 10-20 MG, in ba tare da sakamakon da ake so ba za'a kara zuwa 40 mg. Matsakaicin izinin kyauta na yau da kullum shine MGM 80 kowace rana.

Fluvastatin

An tsara nauyin shan magani na miyagun ƙwayoyi a cikin kashi 20-40 MG kowace rana, amma kashi mafi kyau shine 80 MG kowace rana. An ba shi izini ga marasa lafiya da suka karbi cytostatics bayan sassan jiki.

Lovastatin

Lovastatin ita ce kawai ka'idar halitta. Samu daga naman gwari Aspergillus terreus. Farawa na farko shine 20 MG kowace rana. An yi amfani da shi sau ɗaya, da dare, bayan abincin dare. A wasu lokuta, ana ƙara yawan kuɗin yau da kullum zuwa 40 MG kowace rana. Kusan ba a yi amfani dashi ba a aikin likita saboda bayyanar magungunan analog na zamani.