Medicine "Cyclophosphamide": umarnin don amfani, price, analogs, m da kuma sake dubawa

"Cyclophosphamide" shi ne wani alkylating fili. Wannan magani antitumor wakili. An samar da wani farin ko kusan wannan crystalline foda. Karin bayani game da wannan miyagun ƙwayoyi.

"Cyclophosphamide" - m

Make da miyagun ƙwayoyi a Rasha kamfanin JSC "Biochemistry." An located a garin Saransk a kan titi Vasenko, d. 15A.

kudin na

za ka iya saya da foda №1 «Cyclophosphamide" a wani ɗakin shan magani. Its farashin ne a kusa da 90-98 rubles.

Da miyagun ƙwayoyi siffofin

Daga wannan foda, da mafita a shirye. Yana ne aka yi nufi ga intramuscular da kuma igiyar jini gwamnati

Features abun da ke ciki

A abun da ke ciki na kowane vial tare da foda hada da aiki irin abu da ake kira "cyclophosphamide". Wasu ne lambar. Wato ya ƙunshi "Cyclophosphamide" 200 MG na ce abu da vial. Wannan magani samfurin ba excipients.

Description na pharmacological mataki

Bisa ga umarnin don amfani, "Cyclophosphamide" - shi ne wani alkylating cytostatic miyagun ƙwayoyi. Its sinadaran abun da ke ciki shi ne kama da abubuwa irin su nitrogen mustard. Pharmacological sakamako "cyclophosphamide" shi ne a aiwatar da su kẽta irin crosslinking tsakanin DNA da RNA strands. Har ila yau, wannan shiri na inganta gina jiki kira hanawa.

"Cyclophosphamide" - analogues

A wannan yanayin, karba kudi da ta dace da code Ath hudu category. Quite peculiar ne "Cyclophosphamide". Analogs wannan magani akwai wani babba lambar. Mafi na kowa ne:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

A selection na kowane daga cikin shirye-shirye yi da likita a kan wani mutum akai. A wannan yanayin, yana daukan la'akari da kiwon lafiya da kuma juriya aka gyara.

A wasu lokuta, mai?

Bari mu yi la'akari da wannan batu a more daki-daki. Quite peculiar ne da yin amfani da irin wannan magani kamar yadda "Cyclophosphamide". Umarnin don amfani a wannan batun ne ba makawa kayan aiki. Ya furta cewa, da miyagun ƙwayoyi ne aka nuna a cikin wadannan lokuta:

1. Idan ka fuskanci kullum da kuma m lymphocytic cutar sankarar bargo.
2. A gaban mahara myeloma.
3. Idan cututtuka na ba-Hodgkin lymphoma.
4. A taron na mycosis fungoides da retinoblastoma.
5. A gaban Hodgkin ta cutar da ovarian da nono cancers.
6. Lokacin da bayyanuwar bayyanar cututtuka na neuroblastoma.

Bayan duk wannan, da miyagun ƙwayoyi da ake amfani a hade tare da sauran kwayoyi antitumor jamiái domin lura da wadannan yanayi:

1. Lokacin da jam cell siffofin maruran.
2. Mafitsara ciwon daji da kuma huhu.
3. Sarcoma na taushi da nama irin.
4. A taron na prostate da cutar sankarar mahaifa.
5. Lokacin da Ewing ta sarcoma.
6. A cikin hali na Wilms 'siffofin maruran.
7. Lokacin da retikulosarkome.

Har ila yau, irin wannan shiri a matsayin "Cyclophosphamide", martani wanda ne tabbatacce, shi ne tasiri a matsayin immunosuppressive wakili irin tare da m bayyanuwar autoimmune cututtuka. A wannan yanayin yana nufin bayyanar psoriatic da rheumatoid amosanin gabbai, autoimmune hemolytic anemia, collagen, nephrotic ciwo. Har ila yau ya ce hanyar cike dasa kin amincewa dauki.

contraindications

"Cyclophosphamide" yana da wasu contraindications. Yana ba za a iya amfani da:

1. A lokacin da nono lokacin da ciki.
2. A alama take hakkin bargo aiki.
3. Idan bayyanar cututtuka na hypersensitivity.
4. Lokacin da bata lokaci ba urination.
5. A gaban aiki cututtuka.
6. A lokacin bayyanuwar cystitis.

A hankali shi ne dole "Cyclophosphamide", analogues na wanda aka jera a sama, an gudanar a wasu lokuta. Wato, a gaban wadannan cututtuka:

1. Nefrourolitiaza.
2. Mai tsananin cututtukan zuciya, hanta da koda.
3. Gout.
4. Ƙari infiltration na bargo Kwayoyin.
5. Adrenalectomy.
6. Danniya da bargo aiki.

Description of illa

"Cyclophosphamide", ma'ana (analogues) wanda ake kayyade sama, na iya taimakawa wajen zuwa fitowan da wadannan illa:

1. Narkewa kamar tsarin iya bayyana bayyanar cututtuka irin su amai da tashin zuciya, anorexia, rashin jin daɗi, stomatitis, zafi a cikin ciki yankin, zawo ko maƙarƙashiya. Har ila yau a san ne mutum lokuta na jaundice da hemorrhagic colitis.
2. A hematopoietic tsarin bayyananen aka lura neutropenia, anemia, thrombocytopenia, leukopenia. A ranar 7-14 liyafar iya dan kadan rage yawan platelets da leukocytes.
3. A fata manifestations alopecia kiyaye. Girma gashi sake bayan cikakken magani. Bugu da kari, a lokacin jiyya na iya faruwa a kan fata kurji. Akwai iya zama gaban pigmentation na fata da kuma ƙusa canje-canje.
4. A cikin zuciya da jijiyoyin jini tsarin lokacin gudanar da babban allurai da miyagun ƙwayoyi a kan wani dogon lokaci lokaci zai iya zama wata alama cardiotoxicity. Yana da muhimmanci a tuna. Bugu da kari, za mu lura da fitowan na hadaddun, da kuma wani lokacin m, lokuta da zuciya rashin cin nasara. Wannan shi ne saboda abin da ya faru na myocarditis hemorrhagic irin.
5. A urinary fili iya sa necrosis na koda tashoshi (ciki har da mutuwa), hemorrhagic cystitis ko urethritis, urinary mafitsara fibrosis. A rare lokuta, da aikace-aikace na high dosages na miyagun ƙwayoyi iya faruwa nephropathy, hyperuricemia kuma koda aiki. A gaban epithelial Kwayoyin a cikin fitsari na iya faruwa.
6. A miciwa iya zama wata alama interstitial na huhu fibrosis.
7. A haihuwa tsarin cuta na iya faruwa oogenesis da spermatogenesis, kuma sterility. Last alama a wasu lokuta kuma zai iya zama babu ja. Mafi yawan mata a cikin aikace-aikace na wakili lura da ci gaban amenorrhea. Bayan da magani, da tsari na sananniya yawanci recovers. Maza da shan miyagun ƙwayoyi iya kai zuwa fitowan da oligospermia ko azoospermia, kazalika da sãɓãwar launukansa digiri na testicular atrophy.
8. A wannan yanayin za a iya lura da rashin lafiyan halayen. Wannan shi ne wata alama ce ta wani fata rash, itching, amya, anaphylactic halayen.
9. Har ila yau a cikin wannan harka akwai iya zama da ya faru na illa. Watau jini da fuska fata, redness, m sakandare marurai, wuce kima sweating, ciwon kai.

siffofin hulda

Lokacin da samun wannan magani, wasu abubuwa da taimako zuwa microsomal hadawan abu da iskar shaka a cikin hanta, na iya aiwatar da tsari jawo microsomal metabolism na cyclophosphamide. Wannan take kaiwa zuwa wasu dalilai. Wato, zuwa manyan samuwar alikiliruyuschego irin metabolites. Wannan rage lokaci ga abin da rabin-rai na cyclophosphamide ne da za'ayi, da kuma kuma qara ta aiki. Cyclophosphamide, wanda aka markedly tsawo da kuma damuarn cholinesterase aiki, reinforces da mataki na suxamethonium. shi ma taimaka wajen rage ko rage gudu da metabolism na hodar Iblis. A sakamakon haka, inganta ko kara tsawon na sakamako da kuma kara hadarin mai guba effects. Wannan yana da wani mummunan sakamako a kan dukan kwayoyin. Bugu da kari, lokaci daya aikace-aikace na allopurinol iya taimakawa wajen mai guba effects a kan bargo.

Lokacin da co-gudanar da cyclophosphamide allopurinol, colchicine, probenecid, sulfinpyrazone iya bukatar gyara allurai protivopodagricakih irin kwayoyi a lura da gout da kuma hyperuricemia. Har ila yau, a lokacin da wannan karuwa iya bayyana nephropathy hadarin da ake dangantawa da ya karu samar da uric acid amfani cyclophosphamide.

A karshen abu zai iya sa wani karuwa a anticoagulant aiki. Tun da wannan kira a cikin hanta rage-rage abubuwan inganta jini clotting da sosai platelet samar. Duk da haka, akwai iya faruwa a rage anticoagulant aiki ta hanyar wani ba a sani ba inji type.

Cyclophosphamide kara habaka da cardiotoxicity na daunorubicin da doxorubicin. Sauran immunosuppressive jamiái (chlorambucil, azathioprine, tacrolimus, corticosteroids, mercaptopurine, da dai sauransu) na iya kara yiwuwar sakandare cututtuka da kuma siffofin maruran.

A lokaci daya amfani da lovastatin a marasa lafiya tare da zuciya dasawa iya kara hadarin cututtuka irin rhabdomyolysis da m na koda gazawar.

Idan a hade tare da wannan magani da ake amfani da myelosuppressive kwayoyi ko radiation far, shi ne zai yiwu bayyanuwar ƙari hanawa na bargo aiki.

Lokaci daya gwamnatin cytarabine a high allurai da wani abu kamar cyclophosphamide, a shiri mataki bargo dasawa aiwatar take kaiwa zuwa cardiomyopathy tare da kara mita farko na mutuwa.

Babban sharudda

A cikin aikace-aikace daukan la'akari da wadannan:

1. A lokacin jiyya da wannan magani ya kamata a kai a kai gudanar da wani jini gwajin tantance mataki na myelosuppression. Shi ne musamman zama dole domin kula da yawan platelets da neutrophils.
2. Ya kamata ka ma a kai a kai daukawa fitar da wani fitsari gwajin for gaban ja jini cell count. Kasancewarsu iya bayar da gudummawa ga ci gaban irin wannan cututtuka kamar hemorrhagic cystitis. Bayan ganewa na irin cututtuka magani da "Cyclophosphamide", farashin abin da aka jera a sama, dole ne ka daina.
3. Kamar yadda yawan platelets (kasa da 100,000 / ml) da / ko farin jini Kwayoyin (<2500 / L) na samun hanyar da ya kamata a tsaya.
4. Lokacin da kamuwa da cuta yakan faru a cikin lokacin da miyagun ƙwayoyi far, ya ce magani ya kamata a daina ko katse. Ko dai a game da samun da sashi ya kamata a rage. Maza da kuma mata a lokacin jiyya da tsari, "cyclophosphamide" wajibi ne a yi amfani da abin dogara da hanyoyin da maganin hana haihuwa.
5. A lokacin far tare da wannan magani bukatar sha giya.
6. A cikin akwati inda elapse farko kwanaki goma bayan da aiki, wanda aka za'ayi a karkashin janar maganin sa barci, da kuma haƙuri ana wajabta "Cyclophosphamide", farashin abin da aka jera a sama, ya kamata ka sanar da anesthesiologist sa.
7. Haƙuri bayan ya aka gudanar adrenalectomy, shi wajibi ne a gudanar da rike wani sashi gyara a matsayin corticosteroids, wanda ake amfani da maye far tsari, da kuma irin wannan magani, a matsayin magani, "Cyclophosphamide".

dole riƙi shirinsu

Yanayin aiki na da miyagun ƙwayoyi ne zai yiwu ne kawai a karkashin kulawa da likita wanda ke da kwarewa a jiyyar cutar sankara. Ya kamata kuma a tsananin yarda da sashi tsarin mulki. Wannan ya kamata a yi musamman a hade far. Har ila yau, ba ka bukatar ka ciyar da gaba cire tallafin da kashi idan baya daya da aka rasa. A cikin shirye-shiryen da wannan magani don amfani a jarirai ba da shawarar yin amfani da diluents wanda dauke da benzyl barasa. Tun da yake wannan za a iya kai wa ga ci gaban m mai guba ciwo. Wato, to bayyanar rayuwa acidosis, CNS ciki, na numfashi rashin cin nasara, koda gazawar, hypotension, seizures, intracranial hemorrhage.

A lokacin dukan hanya na lura bada shawarar a gudanar da jini (1 lokaci na mako daya 100-125 ml). Wannan ya kamata a yi don dalili na rigakafin cututtuka kamar hyperuricemia da nephropathy, wanda shi ne saboda samuwar ƙãra yawa na uric acid. Wadannan cututtuka sau da yawa faruwa a farkon lura lokaci. Har ila yau, kafin ce miyagun ƙwayoyi far kuma a lokacin 72 hours bayan gwamnati ne da shawarar a yi wani m ci (game da 3 lita per day), da amfani da allopurinol (a lokuta na musamman), da kuma nufin abin da ya sa alkaline fitsari. Ga masu rigakafin manifestations hemorrhagic cystitis ne sau da yawa zama dole don gudanar da wani emptying na mafitsara da kuma dauki "UROMITEKSAN". Idan akwai na farko alamun cutar, magani ya ce shirye-shiryen da ya kamata a tsaya har sai da cikakken kawar da duk wani bayyanar cututtuka.

Don attenuate irin dyspeptic mamaki iya dauka cyclophosphamide cikin farko rana a kananan allurai. Complete ko m alopecia, wanda na iya faruwa a lokacin da magani ne reversible kuma bayan da Hakika an rage aiki na al'ada gashi girma. Duk da haka, su launi da tsarin iya zama batun canza.

Idan ka fuskanci jin sanyi, zazzabi, tari ko hoarseness, zafi a cikin ƙananan baya yanki, ko a gefe, mai raɗaɗi ko wuya urination, zub da jini, ko zub da jini, black stools, jini a cikin stool ko fitsari kamata nan da nan tuntubar likita.

The yiwuwar thrombocytopenia, abu don bukatar kula na musamman a lokacin ayyuka kamar cin zali da kuma hanyoyin da hakori hanyoyin. Ya kamata a kai a kai duba da fata da kuma mucous membranes da igiyar jini shafin. Wannan shi ne domin gane alamun zub da jini. Shi ne kuma dole a iyakance mita na venipuncture kuma ki intramuscular allura. Wajibi ne a sarrafa jini abun ciki a cikin tumbi, aman, fitsari. Wadannan marasa lafiya da matsananci hankali dole yi gusar tsari, yanka mani farce, dentifrices, toothpicks, da dai sauransu filaye A lokaci guda ya kamata a kauce masa tsananin faduwa da sauran raunin. Acetylsalicylic acid da barasa ne ma haramta abin da kara hadarin gastrointestinal zub da jini. A wannan yanayin wajibi ne a yi wani bata lokaci lamba jadawalin (bayan 3-12 watanni bayan na karshe jiyyar cutar sankara Hakika ƙarshe). Yana da kyawawa don kauce wa lamba tare da cututtuka marasa lafiya. A lokacin jiyya da shi wajibi ne su yi amfani da isasshen maganin hana haifuwa matakan.

Lokacin da tuntužar ce miyagun ƙwayoyi da mucosa ko a fata dole ne sosai rinsed tare da bayyana ruwa da rabo, ko da sabulu, bi da bi.

Nono da kuma ciki

Akwai peculiar iyakancewa a wannan batun, wanda yana cikin "Cyclophosphamide". Manual nuna cewa contraindicated ne yin amfani da wannan magani a lokacin daukar ciki. A wannan yanayin, da category na tasiri a kan tayin denoted «D» da FDA. A lokacin jiyya da shi wajibi ne don yanke nono.

yawan abin sama

A wannan yanayin, akwai wasu nuances. A gaban wani takamaiman maganin guba tare da wani yawan abin sama na ce halitta ne ba a sani ba. Yana da wani m hujja. A yawan abin sama aikace-aikace dole yi goyon bayan matakan da suka hada da dace magani daga cututtuka, kazalika da aukuwar cardiac da / ko myelosuppression.

ajiya yanayi

A wannan batun, shi bukatar wani yanayi irin wannan shiri a matsayin "Cyclophosphamide". Umurnai na amfani tanadi cewa, dole ne a adana a yanayin zafi ba wucewa 10 ° C a wani wuri cewa ya bushe da kuma kare su daga haske. A wannan yara damar shiga ya kamata a ƙuntata.

shiryayye rai

Akwai wasu lokaci a lokacin da irin wannan magani za a iya amfani da a matsayin "Cyclophosphamide". Umurnai na amfani na nuni da cewa ta aiki rayuwa ne shekaru 3. A wannan yanayin, ya kamata ka bi wasu yanayi. Shi ya ta'allaka ne da cewa tsananin haramta yin amfani da wannan magani bayan wannan lokaci ya ƙare.

aiwatar

A wannan shugabanci, akwai kuma wani yanayin da cewa shi ne "Cyclophosphamide". Umarnin a kan aikace-aikace na nuni da cewa da miyagun ƙwayoyi da aka saki kawai a Pharmacy ta sayen magani.

ƙarshe

A wannan rubutu, akwai mai yawa da amfani bayanai. Kuma kamar abin da yake a "Cyclophosphamide", umarnin don amfani, farashin wannan miyagun ƙwayoyi. Duk da haka, ya kamata mutum ya tuna cewa kafin da ake ji da miyagun ƙwayoyi kamata shawarci tare da m likita.